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Pathogen research abs 1 || Pathogen research abs 2 || Pathogen research abs 3 || Pathogen research abs 4 || Pathogen research abs 5 || Hormone and endocrine research abs 1 || Hormone and endocrine research abs 2 || Hormone and endocrine research abs 3 || Hormone and endocrine research abs 4 || Hormone and endocrine research abs 5 || Follicle and follicular cells research abs 1 || Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs







Anticancer Res. 2003 Mar-Apr;23(2A):895-8.
Pro-gastrin-releasing peptide (Pro-GRP), a tumor marker for small cell lung cancer.

Oremek GM, Sapoutzis N.

Klinikum der Johann-Wolfgang Goethe-Universitat Frankfurt, Zentrallabor-Zentrum Innere Medizin, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.

INTRODUCTION: Gastrin-releasing peptide (Pro-GRP), a member of the bombesin family of peptides, has been shown to have mitogenic activity in small cell lung carcinoma (SCLC), and to be produced by SCLC in an autocrine fashion. We investigated the usefulness of serum pro-gastrin-releasing peptide (Pro-GRP) as a tumor marker for diagnosis, treatment and monitoring of patients with small cell lung cancer (SCLC). MATERIALS AND METHODS: This study comprised 80 healthy individuals. Serum samples were also obtained from 80 patients with small cell carcinoma, 20 with chronic bronchitis, 30 with sarcoidosis and 20 with lung fibrosis. The cut-off level of serum Pro-GRP was set at 34.2 pg/ml. RESULTS: The levels of Pro-GRP in the patients with benign diseases were significantly higher than those in the healthy group. The serum Pro-GRP levels were elevated in SCLC patients. The elevation was significantly higher than that of the benign reference group. CONCLUSION: These results show that Pro-GRP may be a potential tumor marker for small cell lung carcinoma.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12820319&dopt=Abstract



Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Apr;24(4):304-6.
[Study on the diagnostic test with C-reactive protein in elderly patients with infections]

[Article in Chinese]

Hu XL, Wang L, Yang W, Yu W, Yue XH, Liu YH, Chu R, Wang Y.

General Hospital of Shenyang Military Region, Shenyang 110015, China.

OBJECTIVE: To evaluate the value of C-reactive protein (CRP) to diagnostic test in elderly patients with infections. METHODS: C-reactive protein were investigated in 142 elderly patients with infections and 216 elderly patients without. CRP 7 - 20, 21 - 40 and 41 - 60 mg/L were stratified, the index of diagnostic test counted. RESULTS: Concentrations of CRP in patients with different diseases were upper respiratory tract infection 36.9 mg/L +/- 28.9 mg/L, acute bronchitis 30.1 mg/L +/- 28.1 mg/L, pneumonia 55.9 mg/L +/- 32.9 mg/L, urinary infection 49.0 mg/L +/- 27.6 mg/L and enteritis 39.3 mg/L +/- 35.6 mg/L. They were all higher than those in control group (5.2 mg/L +/- 2.9 mg/L, P < 0.001). Stratified analysis disclosed that the specificity of CRP was 83.3% - 99.0% for diagnostic infection disease. The positive likelihood ratio (LR) of 7 - 20, 21 - 40 and 41 - 60 mg/L were 3.6, 27.0 and 128.0, respectively. CONCLUSION: C-reactive protein was an important marker to diagnose elderly patients with infections.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12820951&dopt=Abstract [PubMed - in process]



Klin Lab Diagn. 2003 May;(5):3-5.
[In Process Citation]

[Article in Russian]

[No authors listed]

Bronchoalveolar lavage (BAL) was studied in 16 patients with bronchial asthma. Overall metabolites of nitric oxide and malonic dialdehyde were measured. Correlations were established between the concentrations of biologically active compounds and lung ventilation in exacerbation and remission. Lipid peroxidation is closely related with inflammation in both the disease and in health, and is not related with disorders in lung ventilation. Nitric oxide metabolites are different: gas secretion in the exacerbation of bronchial asthma is higher than in chronic obstructive bronchitis. In remission, the nitric oxide activity is low, while it was higher in patients with bronchial asthma as compared with healthy persons.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12822296&dopt=Abstract [PubMed - in process]



Am J Respir Crit Care Med. 1999 May;159(5 Pt 1):1600-4.
Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma.

Hamid QA, Wenzel SE, Hauk PJ, Tsicopoulos A, Wallaert B, Lafitte JJ, Chrousos GP, Szefler SJ, Leung DY.

Divisions of Allergy-Immunology, National Jewish Medical and Research Center, Denver, Colorado, USA.

Glucocorticoid (GC)-insensitive asthma is a challenging clinical problem that can be associated with life-threatening disease progression. The molecular basis of GC insensitivity is unknown. Alternative splicing of the GC receptor (GCR) pre-mRNA generates a second GCR, termed GCRbeta, which does not bind GC but antagonizes the transactivating activity of the classic GCR. Thus increased expression of GCRbeta could account for glucocorticoid insensitivity. Bronchoalveolar lavage (BAL) cells and peripheral blood mononuclear cells (PBMC) were examined for GCRbeta immunoreactivity using a GCRbeta-specific antibody by immunohistochemical staining. Cell localization of GCRbeta expression was performed using a double immunostaining technique. Patients with GC-insensitive asthma expressed a significantly higher number of GCRbeta-immunoreactive cells in their BAL and peripheral blood than GC-sensitive asthmatics or normal control subjects. Furthermore, GCRbeta expression in GC-insensitive asthma was particularly high in airway T cells, which are thought to play a major role in the pathogenesis of asthma. We also examined the expression of GCRbeta in specimens from the airways of patients with chronic bronchitis. In chronic bronchitis, few cells were GCRbeta-positive and their numbers did not differ significantly from normal control subjects. We conclude that GC-insensitive asthma is associated with increased expression of GCRbeta in airway T cells.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10228133&dopt=Abstract








Loss of hair changes the appearance of a person, and the identity of the person in social context to a certain extent. Hair growth is a complex biological process, which has not yet been completely understood. A multitude of therapeutic measures, including drugs, surgery, and suppelements have been made available, and used. However, due to the diversity of the problems underlying hair loss, there is no single solution for all hair loss cases. Most of chemical drugs and hair transplantation surgeries are not free from varying degrees of undesirable side effects on health.

Hair Million is an alternative solution to hair loss problems. Albeit only anecdotally, it has demonstrated efficacy in the improvement for age-related hair thinning and hair loss for a significant fraction of people who take it as recommended. We do not know the mechanisms of action as to how Hair Million works to help stop hair loss, and promote hair growth. We only know by anecdotal observations. There has been no clinical trials nor placebo controlled statistical analysis.
















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