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Ann Rheum Dis. 2003 Aug;62(8):778-80.
Alopecia areata and relapsing polychondritis or mosaic autoimmunity? The first experience of co-trimoxazole treatment.

Rozin AP, Schapira D, Bergman R.

The B Shine Department of Rheumatology, Rambam Medical Centre and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. nahiambam.health.gov.il

A 13 year old girl presented with auricular chondritis and recurrent episodes of unexplained chest pain, arthritis, bronchitis, conjunctivitis, prolonged steroid resistant alopecia areata, and a history of recurrent tonsillitis. Both the mosaic of autoimmunity and relapsing polychondritis were considered in the differential diagnosis. The patient was successfully treated with co-trimoxazole. The significance of co-trimoxazole, which is an antibiotic and an immunomodulatory drug, in the treatment of autoimmune disease is discussed.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12860737&dopt=Abstract

Vestn Ross Akad Med Nauk. 2003;(6):9-12.
[In Process Citation]

[Article in Russian]

[No authors listed]

A total of 189 children with bacterial complications of the acute respiratory viral infection (ARVI)--primarily with pneumonia and bronchitis--were dynamically examined for typical and atypical pneumotropic causative agents of the infection process (Mycoplasma pneumoniae, Chlamydia spp., Streptococcus pneumoniae, Haemophilus influenzae, Pneumocystis carini, and Citomegalovirus). A high frequency rate of the associative infection involving mycoplasmas and pneumocysts was registered (45-50%); it was lower in the cases involving Chlamydias, hemophilic bacteria, pneumococcus, and cytomegalovirus--up to 25-30%. No sharp difference was found between the indices of an infection degree and those of an active clinical infectious process involving the same pneumotropic agent: the biggest difference was observed in Chlamydia infections (9.4%) and the lowest one--in mycoplasma infections (3%). A dynamic comparison of different classes of immunoglobulins revealed that, in acute bronchitis and pneumonias, the Chlamydia and cytomegalovirus infections are, primarily, of the persistent nature; the hemophilic and pneumocystic infections are of a mixed nature; and the pneumococcus one is of the acute nature. The Mycoplasma infection, which is more often encountered in pre-school children, is of the primary type with a trend towards a prolonged clinical course. All pneumonias had a typical clinical course; the clinical picture was compared in 128 patients with the etiological factor (including a description of characteristic symptoms).

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12861708&dopt=Abstract [PubMed - in process]

Int J Circumpolar Health. 2003 May;62(2):142-57.
Does living in a cold climate or recreational skiing increase the risk for obstructive respiratory diseases or symptoms?

Kotaniemi JT, Latvala J, Lundback B, Sovijarvi A, Hassi J, Larsson K.

Department of Pulmonary Medicine, Paijat-Hame Central Hospital, Lahti, Finland. jyrki.kotaniemhks.fi

OBJECTIVES: Respiratory symptoms and obstructive pulmonary diseases experienced during exercise and in cold weather were analysed in a large postal questionnaire study of a general adult population living in a cold climate. The aim of this study was to assess the prevalence of shortness of breath (SOB) during exercise, or in cold weather, and to find out if the risks (odds ratio=OR) for asthma, chronic bronchitis, or SOB during exercise, or in cold weather, were affected by recreational cross-country skiing, or by outdoor work in a cold climate. RESULTS: Of the 7937 invited persons, 84% responded; 876 of them were outdoor workers and 1497 were recreational cross-country skiers. Of the non-smoking responders, asthmatic subjects had the highest prevalence of SOB during exercise in cold weather (78%-82%), but allergic and bronchitic persons also had significantly higher prevalence rates (22%-38% and 27%-59%, respectively) than healthy persons (10%-19%). In all categories, the prevalence of SOB was significantly higher among current smokers than among ex- or non-smokers. Risk factor analysis revealed increased risks for respiratory conditions among those who had a family history of obstructive airway disease, or allergy. Skiers did not have a significantly increased risk for asthma, or respiratory symptoms. Among outdoor workers the risk for SOB during exercise in cold weather, OR 1.23 (CI 1.03-1.47), and for chronic bronchitis, OR 1.77 (CI 1.21-2.60), was higher than among indoor workers. CONCLUSIONS: In conclusion, the risk for chronic bronchitis and bronchitic symptoms was elevated among outdoor workers, but not among regular recreational cross-country skiers, and the risk for asthma was not significantly elevated by regular exercising, or by working in a cold climate.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12862178&dopt=Abstract

J Int Med Res. 2003 May-Jun;31(3):157-69.
Oral telithromycin 800 mg once daily for 5 days versus cefuroxime axetil 500 mg twice daily for 10 days in adults with acute exacerbations of chronic bronchitis.

Zervos MJ, Heyder AM, Leroy B.

William Beaumont Hospital, Royal Oak, MI, USA. mzervoeaumont.edu

The efficacy and safety of a 5-day regimen of 800 mg telithromycin once daily was compared with a standard 10-day regimen of 500 mg cefuroxime axetil twice daily in a multicentre, randomized, double-blind, parallel-group trial involving 376 patients with acute exacerbations of chronic bronchitis (AECB). In clinically evaluable patients (n = 282), post-therapy clinical cure rates were 86.4% with telithromycin and 83.1% with cefuroxime axetil. In bacteriologically evaluable patients (n = 53), eradication or presumed eradication of the pathogen was achieved in 76.0% and 78.6% of telithromycin and cefuroxime axetil patients, respectively. Adverse events were mostly mild; the most common were diarrhoea (12.8% versus 11.8%) and nausea (8.9% versus 3.2%) in telithromycin and cefuroxime axetil patients, respectively. The 5-day regimen of 800 mg telithromycin once daily was similar in efficacy and equally well tolerated as a 10-day regimen of 500 mg cefuroxime axetil twice daily in adults with AECB.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12870368&dopt=Abstract [PubMed - in process]

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