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Am Rev Respir Dis. 1978 Feb;117(2):233-8.
Type-specific pneumococcal respiratory disease in the elderly and chronically III.

Valenti WM, Jenzer M, Bentley DW.

Type-specific pneumococcal respiratory disease was studied in a chronic-disease hospital during a 27-month period. Isolates from 50 patients with pneumonia and from 24 patients with chronic bronchitis were available for typing. Vaccine types were isolated from 74 per cent of patients with pneumonia and from 42 per cent of patients with chronic bronchitis. Pneumococcal types isolated from 5 of 8 patients with bacteremia and from 6 of 9 patients who died were also included in the vaccine. The data suggest that, theoretically, closed populations of elderly and chronically ill patients would benefit from vaccination in an attempt to control pneumococcal pneumonia. Less clear is the potential role vaccination in patients with chronic bronchitis.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25032&dopt=Abstract

Br J Dis Chest. 1978 Apr;72(2):115-21.
Exacerbations of chronic bronchitis: exogenous or endogenous infection?

Ellis DA, Anderson IM, Stewart SM, Calder J, Crofton JW.

Six male patients with chronic bronchitis, who were known previously to have excreted Streptococcus pneumoniae and/or Haemophilus influenzae, both at the times of exacerbations and during remission, were studied for 43 to 52 months. Sputum was examined fortnightly and at the time of exacerbations. Strains of Strep. pneumoniae were serotyped and those of Haemophilus species were typed by antibiograms along with other supporting methods. Sera collected before or at the time of an exacerbation and seven and 30 days afterwards were examined by complement fixation tests against respiratory viruses and Mycoplasma pneumoniae. In 18 out of 25 exacerbations there was evidence of a new type of Strep. pneumoniae and/or Haemophilus spp. or of a current virus infection, suggesting exogenous infection in the majority of these cases. There was a possible reason for failure to detect a new pathogen in three of the seven cases in which none was found. In five further exacerbations adequate investigation was not possible.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25664&dopt=Abstract

Infection. 1978;6(2):54-6.
Bacteriological findings in the transtracheal aspirate from patients with acute exacerbation of chronic bronchitis.

Schreiner A, Bjerkestrand G, Digranes A, Halvorsen FJ, Kommedal TM.

Transtracheal aspirates from 87 patients with acute exacerbations of chronic bronchitis who had received no recent antibiotic treatment were examined. A single bacterial species was found in 83% of positive cultures. Predominant pathogens were Haemophilus influenzae and Streptococcus pneumoniae which occurred jointly or separately in 50% of positive cultures. Bacteria traditionally considered as non-pathogenic for the lower respiratory tract also appeared to play an aetiological role. Enterobacteriaceae and anaerobes were infrequent. No bacterial growth was found in 11 cases.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25845&dopt=Abstract

J Clin Microbiol. 1978 May;7(5):459-62.
Diagnosis of pneumococcal pneumonia by antigen detection in sputum.

Miller J, Sande MA, Gwaltney JM Jr, Hendley JO.

Pneumococcal polysaccharide was detected by counterimmunoelectrophoresis in the sputum of 20 of 26 (77%) adults with community-acquired pneumonia and a positive sputum culture for Streptococcus pneumoniae. The test was negative in 29 pneumonia patients with negative sputum culture for S. pneumoniae.Pneumococcal antigen was also detected in the sputum of six of nine adults with chronic bronchitis and a positive sputum culture, but was not detected in expectorated respiratory secretions of 22 pneumococcal carriers with colds. Pneumococcal antigen could also be detected in sputum by immunodiffusion; antigen titers varied from 1:2 to 1:256. These results strongly suggest that the detection of pneumococcal antigen in respiratory tract secretions indicates infection caused by S. pneumoniae.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26694&dopt=Abstract

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