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Pathogen research abs 1 || Pathogen research abs 2 || Pathogen research abs 3 || Pathogen research abs 4 || Pathogen research abs 5 || Hormone and endocrine research abs 1 || Hormone and endocrine research abs 2 || Hormone and endocrine research abs 3 || Hormone and endocrine research abs 4 || Hormone and endocrine research abs 5 || Follicle and follicular cells research abs 1 || Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs

Allerg Immunol (Leipz). 1977;23(3):199-205.
Local specific immunity in infants with spastic bronchitis and bronchopneumonia.

Kikindjanin V.

In 27 infants with spastic bronchitis and in 23 infants with bronchopneumonia the values of IgA, IgG and IgM in bronchial secretion were determined by single radial immunodiffusion method. In both group A and B the frequencies of IgA and IgG were statistical significant. The IgM frequency was significant only in group A. The mean values of IgA and IgG were considerably higher in relation to mean IgM values. The presence of IgA and IgG was found in the first bronchial secretion sample in all investigated infants. The presence of IgM in bronchial secretion was found in high percentage. However, the presence of IgM was found in ten investigated infants only in second bronchial secretion sample. It was concluded that for estimation of real state of specific local immunity on bronchial mucosa it is necessary to determine the immunglobulin values twice and that at three days interval. In this study the local immunoglobulin deficiency was found in none case.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=147017&dopt=Abstract

Sao Paulo Med J. 2002 Jul 4;120(4):100-4.
Cost-effectiveness of hypertension treatment: a population-based study.

Dias da Costa JS, Fuchs SC, Olinto MT, Gigante DP, Menezes AM, Macedo S, Gehrke S.

Departamento de Medicina, Faculdade de Medicina, Universidade Federal de Pelotas, Rio Grande do Sul, Brazil. jsdfpel.tche.br

CONTEXT: The cost-effectiveness of the treatment of hypertension has scarcely been investigated in population-based studies. Most data come from secondary analysis of clinical trials and administrative sources. OBJECTIVE: To describe the health care costs for outpatient hypertension treatment in comparison with diabetes mellitus and chronic bronchitis, and to examine the cost-effectiveness of different classes of antihypertensive drugs. DESIGN: Cross-sectional population-based study. SETTING: Urban area of Pelotas, southern Brazil. PARTICIPANTS: Individuals aged 20-69 years, identified through multi-stage probability sampling. METHODS: Participants were interviewed at home. Demographic data, education, income, smoking, previous morbidity, use of medicine and other characteristics were assessed via a pre-tested questionnaire, and blood pressure while seated was measured in a standardized way. RESULTS: Approximately 24% of the participants had high blood pressure or were taking antihypertensive drugs, and among these, 33% had had a physician consultation during the month preceding the interview. The monthly mean costs of care for hypertension (R$ 89.90), diabetes (R$ 80.64) and bronchitis (R$ 92.63) were similar. Treatment of hypertension consumed 22.9% of the per-capita income, corresponding to R$ 392.76 spent per year exclusively on antihypertensive drugs. Most of the direct costs associated with hypertension and diabetes were spent on drugs, while patients with bronchitis had greater expenditure on appointments. The cost-effectiveness relationship was more favorable for diuretics (116.3) and beta blockers (228.5) than for ACE inhibitors (608.5) or calcium channel blockers (762.0). CONCLUSION: The costs of hypertension care are mainly dependent on the expenditure on blood pressure-lowering drugs. Treatment of hypertension with diuretics or beta blockers was more cost-effective than treatment with ACE inhibitors and calcium channel blockers.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12436155&dopt=Abstract

Allerg Immunol (Leipz). 1977;23(4):273-80.
Clinical signifcans of longitudinal determination of immunoglobulin values in infants with acut respiratory diseases.

Kikindjanin V.

The immunoglobulin values (IgM, IgA, IgG) were determined longitudinally in 73 infant with acute obstructive bronchitis; with acute obstructive bronchitis associated with bronchopneumonia; with bronchopneumonia. The immunoglobulin values were determined by single radial immunodiffusion method. The comparison of time of clinical recovery and x-ray clearing on the one hand and the normalisation of immunoglobulin values on the other hand was done too. It was found that the high immunoglobulin values were maintained after the clinical recovery and x-ray clearing the longest period of time in infants with acut obstructive bronchitis. In infants with acute obstructive bronchitis associated with bronchopneumonia the high immunoglobulin values were maintained very long but they were normalised on the 34-30th day of clinical recovery and x-ray clearing. In infants with bronchopneumonia the high immunoglobulin values were maintain considerably shorter and they were normalised on the 6th day after the clinical recovery. Whit regard to different time of normalisation of immunoglobulin values in infants with acute obstructive bronchitis associated with bronchopneumonia it was concluded that the longitudinal determination of immunoglobulin values has clinical significance since it can be found which of these two diseases is dominant.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=147616&dopt=Abstract

Respir Med. 2000 Sep;94(9):847-51.
Neither IL-1beta, IL-1 receptor antagonist, nor TNF-alpha polymorphisms are associated with susceptibility to COPD.

Ishii T, Matsuse T, Teramoto S, Matsui H, Miyao M, Hosoi T, Takahashi H, Fukuchi Y, Ouchi Y.

Department of Geriatric Medicine, University of Tokyo, Japan.

The cytokines that contribute to airway inflammation, including interleukin-1beta (IL-1beta) and tumour necrosis factor alpha (TNFalpha), might have key roles in the development of chronic obstructive pulmonary disease (COPD). Interleukin-1 receptor antagonist (IL-1RN), the physiological antagonist of IL-1beta, is also known to play a crucial role in several chronic inflammatory diseases. In this study, we investigated the association of the polymorphisms of IL-1beta, IL-1RN and TNFalpha with susceptibility to COPD. To elucidate the genotype of the IL-1beta polymorphisms at position -511 base and at the amino acid residue 105, the IL-1RN polymorphism in intron 2, and TNFalpha polymorphism at position -308, polymerase chain reaction (PCR) and restriction enzyme fragment length polymorphism (RFLP) were performed on blood samples from both patients with COPD (n = 53) and control subjects (n = 65). There were no differences on the allele and genotype frequency of IL-1beta, IL-1RN, and TNFalpha between the two groups. We could not find a significant link between the polymorphism of TNFalpha, which was previously reported to be associated with chronic bronchitis, and COPD. Furthermore, no association between genetic polymorphisms of IL-1beta and IL-1RN and individual susceptibility to COPD was found.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11001075&dopt=Abstract

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