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Cancer Causes Control. 2000 Oct;11(9):853-8.
Previous lung disease and lung cancer risk among women (United States).

Brownson RC, Alavanja MC.

Department of Community Health and Prevention Research Center, School of Public Health, Saint Louis University, MO 63108-3342, USA. brownsolu.edu

OBJECTIVE: The association between previous lung diseases (PLD) and lung cancer risk has not been studied extensively. We conducted a registry-based case-control study to examine the relation between previous lung diseases and lung cancer among women in Missouri. METHODS: Incident cases (n = 676) were identified through the Missouri Cancer Registry for the period 1 January 1993 to 31 January 1994. Controls (n = 700) were selected through drivers' license files and Medicare files. RESULTS: Whether analyzing all respondents or in-person interviews only, elevated effect estimates were noted for several types of PLD. Elevated relative risk estimates were shown for chronic bronchitis (odds ratio [OR] = 1.7; 95% confidence interval [CI] = 1.2-2.3), emphysema (OR = 2.7; 95% CI = 1.8-4.2), pneumonia (OR = 1.6; 95% CI = 1.2-2.0), and for all PLDs combined (OR = 1.5; 95% CI = 1.2-1.9). Analysis of only direct interviews did not show a substantial or consistent pattern of change in relative risk estimates. Because PLDs identified close to the time of cancer diagnosis could conceivably be misdiagnosed, resulting from early lung cancer symptoms, we evaluated the effects on risk estimates of a "latency exclusion" of up to three years. When these exclusions were taken into account, ORs remained statistically significantly elevated only for emphysema. CONCLUSION: When earlier epidemiologic findings and underlying biological and genetic factors are taken into account, an association between PLD and lung cancer is plausible.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11075875&dopt=Abstract

J Epidemiol Community Health. 2000 Dec;54(12):917-22.
Cigarette smoking gives more respiratory symptoms among women than among men. The Nord-Trondelag Health Study (HUNT).

Langhammer A, Johnsen R, Holmen J, Gulsvik A, Bjermer L.

National Institute of Public Health, Community Medicine Research Unit, Neptunveien 1, N-7650 Verdal, Norway. verdalfnline.no

STUDY OBJECTIVE: Studies have indicated that women are more vulnerable to the effect of tobacco smoking compared with men. The aim of this study was to explore the prevalence of reported respiratory symptoms and diseases according to smoking burden, age and sex. DESIGN: Questionnaire in a cross sectional population based study. SETTING: The BONT (Bronchial obstruction in Nord-Trondelag) study is part of a comprehensive health survey of all inhabitants aged above 19 years in the county of Nord-Trondelag, Norway, which was carried out from 1995 to 1997. PARTICIPANTS: A total of 65 717 subjects, 71.3% of the total population aged 20-100, answered the main questionnaire. MAIN RESULTS: In all, 12.7% men and 12.1% women reported episodes of wheezing or breathlessness during the past 12 months, 8.8% men and 8.4% women reported that they had or had had asthma, 7.5% men and 8.2% women had ever used asthma medication, and 4.0% men and 3.0% women reported chronic bronchitis. Thirty per cent of men and 31% of women were smokers, and average pack years of smoking were 15.9 and 10.3, respectively. Among previous and current smokers, significant more women reported episodes of wheezing or breathlessness, current asthma and persistent coughing compared with men with the same smoke burden (pack years) and daily number of cigarettes. CONCLUSION: The prevalence of reported asthma and use of asthma medication was higher than reported in previous Scandinavian studies. Respiratory symptoms increased by smoking burden. Comparing the prevalence of symptoms and current asthma among women and men with the same smoke burden or daily cigarette consumption, women seemed to be more susceptible to the effect of tobacco smoking than men.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11076988&dopt=Abstract

Public Health Rev. 1999;27(4):321-8.
Pattern of primary care clinic visits of adult asthmatics.

Ben-Noun L.

Department of Family Medicine, Ben-Gurion University of the Negev, Kiryat Gat, Israel.

BACKGROUND: Although asthma in adult patients is responsible for a large proportion of the morbidity in primary care, there has been little research on the pattern of visits among adult patients with asthma. The objective of this study was to compare the pattern of visits by adult patients with asthma with that by non-asthmatics over one year. METHODS: A case-control study was conduced on a population of 4341 men and women, aged 18 years or older, registered with a primary care clinic. The study group consisted of 141 asthmatics, and the control group, of 423 non-asthmatic subjects. The pattern of visits was examined for asthmatics and compared with non-asthmatic subjects. RESULTS: Respiratory, circulatory, musculoskeletal, and digestive disease categories were the most common reasons for visits for both asthmatics and non-asthmatics, with visits for pregnancy and family planning, trauma, and neoplasm being the least common. The rate of visits was significantly higher in asthmatics than non-asthmatics for respiratory diseases, including asthma, upper respiratory tract infections (URTI), and acute bronchitis, while non-asthmatics had a higher rate of visits for endocrine and metabolic disorders, including diabetes mellitus, low back pain, trauma, urogenital disorders, and pregnancy and family planning. The mean number of visits per patient per year was significantly higher for asthmatic than non-asthmatic subjects. CONCLUSIONS: A different pattern of consultations was observed. Asthmatics visited their doctors more frequently than patients without asthma, mainly consulting for various respiratory problems.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11081357&dopt=Abstract

Ugeskr Laeger. 2000 Oct 23;162(43):5772-7.
[Predicted effect of smoking cessation of tobacco-related mortality]

[Article in Danish]

Bronnum-Hansen H.

Statens Institut for Folkesundhed, Kobenhavn.

INTRODUCTION: Cigarette smoking is a serious threat against public health and the most important preventable cause of death. The purpose of this study is to predict the effect on smoking-attributable mortality in Denmark by reducing the number of cigarette smokers. MATERIALS AND METHODS: The simulation model "Prevent" is used. This model operates with the population size and death rates in 1993, data on cigarette smoking from 1973 to 1992 and relative risks for the association between cigarette smoking and lung cancer, chronic bronchitis and emphysema, ischaemic heart disease and stroke. The influence of reduced cigarette smoking on mortality due to these diseases is studied. The expected effect on a smoke-free year group is estimated and so is the effect of the implementation of targets in the Danish Government's Public Health Programme 1999-2008. RESULTS: For the smoke-free year group death rates of ischaemic heart disease are reduced by one third for men and one half for women compared to unchanged cigarette smoking. Death rates of lung cancer, chronic bronchitis and emphysema would be approx. five times lower. If the proportion of Danish cigarette smokers could be reduced by one third over a period of ten years the reduced mortality due to lung cancer, chronic bronchitis and emphysema, ischaemic heart disease and stroke would increase the population (five mio. individuals) by 25,000 after 20 years. DISCUSSION: Intervention against cigarette smoking, especially among young people, would massively reduce mortality from several diseases in the long term. Also in the short term mortality would be reduced substantially by reducing the number of cigarette smokers.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11082677&dopt=Abstract

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