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Biophys J. 1977 May;18(2):161-72.
Dependence of energy transduction in intact skeletal muscles on the time in tension.

Kawai M, Brandt P, Orentlicher M.

In intact single crayfish muscle fibers and frog semitendinosus muscles we have studied the tension response to sinusoidal length changes in the frequency range of 0.25-133 Hz. By this method we have resolved three processes in the interaction of myosin cross-bridges with actin in fully activated preparations. They are (A) a low-frequency phase advance, (B) a middle-frequency delay, and (C) a high-frequency advance. These processes can be used as probes to study the chemomechanical coupling of contractility. Process (B) represents net power output from the muscle preparation (oscillatory work). With maximal K or caffeine activation of crayfish muscle at 20 degrees C, it decreases to zero in the initial 45 s of maintained tension. Similar results were obtained with frog semitendinosus whole muscles. We interpret this decrease of (B) with time as a gradual decrease in actomyosin ATP-hydrolysis rate.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=140712&dopt=Abstract

Jpn J Physiol. 1977;27(1):95-109.
Dissociation of excitation and contraction in skeletal muscle induced by deuterium oxide and dantrolene-sodium.

Yamamoto Y, Suzuki A, Hotta K.

The effect of D2O and dantrolene-Na (DAN) on the electrical and mechanical responses of single muscle fiber (mouse EDL and frog semitendinosus), Ca2+ uptake and release of sarcoplasmic reticulum (SR) and contractile proteins was investigated to elucidate the coupling mechanism between depolarization and contraction. Both agents inhibited tension development induced by depolarization and caffeine, especially the initial phase of contraction (more pronounced in fast muscle) without affecting excitation of membrane and contractile machinery. The effect of DAN can be antagonized by increasing Ca2+ concentration and lowering the temperature of the medium. Ca2+ uptake and release abilities of isolated SR were not altered significantly in DAN, but were reduced considerably in D2O. These results suggest than there is a Ca2+-mediated trigger mechanism for the rapid release of activator Ca2+ from internal storage (SR). DAN and D2O interfere predominantly the action of the site(s) of this mechanism, probably on the T-tubules. In addition, D2O decelerates Ca2+ release from SR per se.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=140946&dopt=Abstract

Jpn J Pharmacol. 1977 Feb;27(1):145-52.
Possible involvement of a central noradrenergic system in automutilation induced by clonidine in mice.

Razzak A, Fujiwara M, Oishi R, Ueki S.

Automutilation induced by a single large dose of clonidine was potentiated by pretreatment with methamphetamine, caffeine and theophyline, while it was inhibited by acute administration of reserpine, alpha-methyl-p-tyrosine, phenoxybenzamine, phentolamine and chlorpromazine. L-Dopa, 5-hydroxytryptophan and p-chlorophenylalanine had no effect on this abnormal behavior. Biochemical studies on brain monoamines revealed that noradrenaline was markedly increased and dopamine slightly so, but 5-hydroxytryptamine was never changed by clonidine. These results suggest that a central noradrenergic system may be involved in automutilation induced by clonidine in mice.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=140948&dopt=Abstract

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Hair Loss, or alopecia is a concern for increasing number of folks in aging society. Loss of hair is a visible problem, and affects the appearance and changes identity of a person.
The phenomenon of hair thinning and hair loss is most commonly associated with natural aging, although there are many other causes of hair loss, which include inherited or genetic conditions, illnesses, malnutrition, stress, hormonal problems, chemotherapy, and use of some drugs.
Hair growth is a sophisticated biological process, which has not yet been completely understood. A multitude of therapeutic measures, including drugs, surgery, and suppelements have been made available, and used. However, due to the heterogeneity in the underlying cause, there is no perfect cure for all hair loss cases. Most of chemical drugs and hair transplantation surgeries are not free from varying degrees of undesirable side effects on health.

Hair Million is an alternative solution to hair loss problems. Anecdotally, it shows prositive results and improvement for age-related hair thinning and hair loss for a fraction of people who take it. We do not know the mechanisms of action as to how Hair Million works to help stop hair loss, and promote hair growth. We only know by anecdotal observations. There has been no clinical trials nor placebo controlled statistical analysis on the efficacy of Hair Million on hair loss and hair growth. However, there are two merits in this hair restoration herbal formula:
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