Hair Million, for hair growth




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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs







Chemotherapy. 1999 May-Jun;45(3):197-204.
Intrapleural administration of cisplatin and etoposide to treat malignant pleural effusions in patients with non-small cell lung cancer.

Tohda Y, Iwanaga T, Takada M, Yana T, Kawahara M, Negoro S, Okishio K, Kudoh S, Fukuoka M, Furuse K.

Fourth Department of Internal Medicine, Kinki University, Osaka, Japan.

BACKGROUND: To determine the efficacy, toxicity and pharmacokinetics of intrapleural cisplatin (CDDP) and etoposide as a treatment for malignant pleural effusions (MPE) in patients with non-small cell lung cancer (NSCLC). METHODS: Seventy patients with MPE associated with NSCLC were enrolled in this study. In 68 patients, a catheter was inserted into the pleural cavity, within 24 h after complete drainage of the pleural effusion, CDDP (80 mg/m2) and etoposide (80 mg/m2) were simultaneously administered successfully via the catheter and the catheter was clamped. Seventy-two hours later, the catheter was unclamped to allow drainage. The catheter was removed when the accumulated intrapleural fluid decreased to 20 ml or less per day. RESULTS: The pharmacokinetic profiles showed high maximum concentrations of CDDP (free form, 88 microg/ml) and etoposide (182. 4 microg/ml) in intrapleural fluids. CDDP did not remain for a long period (free form, beta-phase half-life = 10.51 h) in the fluids, while etoposide persisted for a long period (beta-phase half-life = 62.53 h). The overall response rate was 46.2%, the median survival time 32.3 weeks, the 1-year survival rate 28.7% and the 2-year survival rate 12.8%. The most serious adverse reactions were WHO grade 3 anemia (3 patients), grade 3 nausea and vomiting (17 patients), grade 3 constipation (1 patient), grade 3 pulmonary toxicity (1 patient), grade 4 fever (1 patient), grade 3 infection (1 patient) and grade 3 mental disorder (1 patient). CONCLUSION: Intrapleural administration of CDDP and etoposide was an effective and acceptable regimen for patients with MPE due to NSCLC.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10224342&dopt=Abstract



ABNF J. 2002 Nov-Dec;13(6):140-4.
Concerns of hospice patient caregivers.

Newton M, Bell D, Lambert S, Fearing A.

School of Nursing, Southern Illinois University at Edwardsville, Edwardsville, IL 62026, USA.

This descriptive study examined the needs and concerns of caregivers who provide care for patients at home, and who are also receiving hospice home care. Services that caregivers need to provide this care was also identified. The settings were two Midwestern, suburban hospices. Thirty-three caregivers participated. Nine participants were males and 24 were female. Ages ranged from 20 through 80 years. Caregivers completed a 28-item semi-structured questionnaire developed by the researchers. Demographic information and caregiver problems with symptom management, time spent giving care, hospice services utilized, other sources of support and assistance were assessed. Open-ended items asked about caregivers' stress levels and about problems that were not resolved by hospice. The study found that the distressing symptoms caregivers found most difficult to manage were constipation, confusion, and anorexia. Caregivers identified lack of mobility and loss of bladder control most frequently as unmanageable symptoms. A majority of respondents identified the hospice nurse as their main source of information regarding care and resource needs and often cited the nurse as a source of emotional support. Sixty-four percent reported that they provided care 12-24 hours per day with some respite from family members. Results of the study indicate that caregivers spend a large amount time with the hospice patients despite use of hospice services and assistance from family members. This can lead to high stress levels and exhaustion. There is a need for more respite care for caregivers. Hospice provides caregivers with needed support, both emotional and with the care itself.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12592831&dopt=Abstract



Pediatr Res. 1999 May;45(5 Pt 1):714-7.
A heterozygous frameshift mutation in the endothelin-3 (EDN-3) gene in isolated Hirschsprung's disease.

Svensson PJ, Von Tell D, Molander ML, Anvret M, Nordenskjold A.

Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Hirschsprung's disease, affecting one in 5000 live newborns, is the most common cause of neonatal intestinal obstruction. The obstruction or, later in life, constipation arises from the lack of enteric ganglia in the hindgut, thus resulting in poor coordination of peristalsis. Mutations in Hirschsprung patients have so far been reported in five genes associated in two different receptor-ligand systems, RET-GDNF/NTN and EDNRB-EDN-3, and an additional gene with yet unknown precise function, SOX10. We report the results of single-stranded conformation polymorphism screening of the endothelin-3 gene in a Swedish population-based material of 66 sporadic and nine familial Hirschsprung's disease cases. We have found a novel heterozygous mutation in exon 2, c.262insG, in a patient with sporadic short segment Hirschsprung's disease without any Waardenburg features. This frameshift results in a premature stop two codons further on. Because this stop is introduced 5' of the biologically active protein, this mutation can hence be predicted to result in haplo-insufficiency.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10231870&dopt=Abstract








Loss of hair changes the appearance of a person, and the identity of the person in social context to a certain extent. Hair growth is a complex biological process, which has not yet been completely understood. A multitude of therapeutic measures, including drugs, surgery, and suppelements have been made available, and used. However, due to the diversity of the problems underlying hair loss, there is no single solution for all hair loss cases. Most of chemical drugs and hair transplantation surgeries are not free from varying degrees of undesirable side effects on health.

Hair Million is an alternative solution to hair loss problems. Albeit only anecdotally, it has demonstrated efficacy in the improvement for age-related hair thinning and hair loss for a significant fraction of people who take it as recommended. We do not know the mechanisms of action as to how Hair Million works to help stop hair loss, and promote hair growth. We only know by anecdotal observations. There has been no clinical trials nor placebo controlled statistical analysis.
















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