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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs

J R Soc Health. 1998 Aug;118(4):237-40.
Lessons to be learned: a case study approach diuretic therapy and a laxative causing electrolyte and water imbalance, loss of attention, a fall and subsequent fractures of the tibia and fibula in an elderly lady.

Sankar NS, Donaldson D.

Department of Trauma and Orthopaedic Surgery, Crawley Hospital, West Sussex.

The case is described of a hitherto well, alert and intelligent lady of 85 years of age, who commenced medication with diuretics--prescribed for mild congestive cardiac failure; she developed constipation consequent upon the diuresis and dehydration thereby provoked. As a result she began to take, unknown to her general practitioner, regular and increasing amounts of laxatives. At about this time she was noted by her son to become "rapidly senile"--with the result that she fell on account of losing her normally good concentration and attention; she sustained fractures of the right tibia and fibula. Shortly after admission to hospital she was premedicated, anaesthetised and operated upon, following which there was a postoperative regimen comprising several litres of low sodium isotonic infusions, all given intravenously. She was found at this point to be severely hyponatraemic with a low serum osmolality, but following the institution of water restriction rapidly improved as her serum sodium rose again; there was an accompanying massive diuresis as the previously retained water was voided. Concomitant with the serum sodium rise her mental concentration and attention regained their former levels. The biochemical and cellular mechanisms underlying this patient's symptoms are discussed.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10076675&dopt=Abstract

Soc Psychiatry Psychiatr Epidemiol. 1999 Jan;34(1):44-7.
Self-reported depressive symptoms among Chinese adolescents.

Liu XC, Ma DD, Kurita H, Tang MQ.

Department of Psychiatry, Shandong Medical University, Jinan, China.

Previous reports on the prevalence and features of depression among adolescents have been inconsistent. The purpose of the current study was to estimate the prevalence of depression among Chinese adolescents with a standardized instrument. A total of 2462 students, aged 13-22, were sampled from the Shandong province of China. The Zung Self-Rating Depression Scale (SDS) was administered to the subjects in their classrooms. It was shown that the mean SDS score was 44.8 (SD 9.9) and it decreased significantly from the age of 18 upward (F = 31.73, df = 9, P < 0.01). No significant difference was found between males and females (t = 0.70, P > 0.05). Taking 55 as a cut-off score, the prevalence rate of depression was 16.9% (95% CI = 15.4-18.4%). Logistic regression showed that increasing age appeared to decrease the risk for depression. Most of the individual items differed between ages, except for weight loss and constipation. Principal components factor analysis revealed that the characteristics of adolescent depression were depressive/anxious mood, psychomotor retardation, loss of self-esteem, somatic symptoms and decreased appetite and libido. Although the study was based on a large sample using an established instrument, the sample was not from a general adolescent population and case ascertainment was not by clinical diagnosis.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10073120&dopt=Abstract

Am J Gastroenterol. 1999 Mar;94(3):609-15.
Physiology of refractory chronic constipation.

Mertz H, Naliboff B, Mayer E.

Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.

OBJECTIVE: Investigators suggest three distinct pathophysiologies for patients with constipation symptoms: 1) slow colon transit, 2) irritable bowel syndrome (IBS), and 3) pelvic floor dysfunction (PFD). Our aim was to determine the prevalence of the three types of constipation pathophysiology, the degree of overlap, and what interactions exist between pathophysiologies. METHODS: Constipated patients refractory to fiber (n = 131) underwent regional colon transit studies, anorectal manometry/EMG, measurement of rectal compliance, and rectal sensory testing. Correlations were performed examining interactions between the above measures. RESULTS: Visceral hypersensitivity (typical of IBS) was found in 58%, slow colonic transit in 47%, PFD in 59%, and no physiological abnormalities were detected in 24%. Slow transit and visceral hypersensitivity overlapped in half of each group. PFD physiology was found in approximately half of each of the subgroups. There was no correlation between PFD physiology and rectosigmoid transit, total colon transit, or any other physiology. There were no correlations between slow transit and visceral hypersensitivity. Visceral hypersensitivity did correlate with increased rectal compliance, suggestive of increased accommodation reflexes in IBS. CONCLUSIONS: At a tertiary center, slow transit physiology and visceral hypersensitivity typical of IBS are equally common and overlap heavily in constipated patients. PFD physiology does not correlate with slower rectosigmoid colon transit, and is seen equally in all subgroups. No abnormalities were found in 24% of patients. We therefore identify four subgroups in constipation: IBS, slow transit, both, and neither.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10086639&dopt=Abstract

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