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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs

Int J Colorectal Dis. 2002 Jul;17(4):253-8. Epub 2002 Jan 15.
Evaluation of myenteric ganglion cells and interstitial cells of Cajal in patients with chronic idiopathic constipation.

Yu CS, Kim HC, Hong HK, Chung DH, Kim HJ, Kang GH, Kim JC.

Colorectal Clinic, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-dong Songpa-gu, Seoul 138-736, Korea. csymc.seoul.kr

BACKGROUND AND AIMS: The aim of this study was to identify myenteric ganglion cells (MGC) and interstitial cells of Cajal (ICC) from the total colectomy specimen in patients with chronic idiopathic constipation. PATIENTS AND METHODS: Fourteen patients who had severe, intractable, long-standing (mean: 14 years) constipation underwent subtotal colectomy and ileorectal anastomosis. All resected specimens were investigated with hematoxylin and eosin (H&E) and immunohistochemical staining with anti-neurofilament monoclonal antibody NF(2)F(11) for MGC, and c-kit antibody for ICC. The numbers of MGC and ICC were counted for ascending (AC), descending (DC), and sigmoid colon (SC). We compared these data with those from ten control specimens. RESULTS: The number of MGC was significantly smaller in AC and DC of the constipated group than in the control group. Interestingly, SC contained a similar number of MGC. The two staining methods were equally effective for identifying MGC. The total ICC number in the constipated group was markedly lower in every segment. Most anatomical layers of the colon, including the submucosal border, circular muscle, and longitudinal muscle, revealed a similar tendency. However, in the myenteric plexus area there was no significant difference between the two groups. CONCLUSION: A quantitative decrease in MGC and ICC appears to be implicated in chronic idiopathic constipation.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12073074&dopt=Abstract

Neth J Med. 2002 Mar;60(1):22-5.
Pneumatosis cystoides intestinalis, four cases of a rare disease.

Rennenberg RJ, Koek GH, Van Hootegem P, Stockbrugger RW.

University Hospital Maastricht, Department of Internal Medicine, The Netherlands.

Pneumatosis cystoides intestinalis (PCI) is a disease in which small gas-filled cysts appear in the intestinal wall. Four cases presented here demonstrate the diversity of the associated diseases. In two of the patients constipation probably played a role; in the third patient decreased colonic motility, elevated intestinal pressure and increased mucosal permeability in the context of enteritis treated with codeine was the underlying problem; in the fourth high protein feeding and bowel ischaemia was diagnosed. Various aetiologies are presented in the literature. There is no specific history and physical or laboratory findings do not help to diagnose PCI. Plain abdominal film, ultrasound, computer tomography, magnetic resonance imaging, barium contrast studies and/or endoscopy may be necessary for diagnosis. Therapy is based on enhancing partial oxygen pressure in the bowel wall. PCI usually runs a benign course.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12074039&dopt=Abstract

Tech Coloproctol. 2002 Apr;6(1):23-6.
Subtotal colectomy with antiperistaltic cecorectal anastomosis.

Sarli L, Iusco D, Violi V, Roncoroni L.

Department of Surgery, University of Parma, School of Medicine, Via Gramsci 14, I-43100 Parma, Italy. leosarlpruniv.cce.unipr.it

We assessed the functional results achieved with an antiperistaltic end-to-end cecorectal anastomosis (CRA) after subtotal colectomy. A total of 34 patients with colonic cancer, inflammatory bowel disease or chronic constipation were treated with subtotal colectomy and cecorectal anastomosis. The postoperative mortality was nil; no major postoperative complication was registered. At a mean 60-month follow-up (range, 12-92), 32 patients were alive, showed no diarrhea nor incontinence, were completely relieved from previous symptoms and abdominal discomfort, and had a normal diet. In conclusion, subtotal colectomy with end-to-end antiperistaltic CRA seems to have a role in selected cases for the treatment of inflammatory bowel diseases, colon tumors and slow-transit constipation.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12077637&dopt=Abstract

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