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Pathogen research abs 1 || Pathogen research abs 2 || Pathogen research abs 3 || Pathogen research abs 4 || Pathogen research abs 5 || Hormone and endocrine research abs 1 || Hormone and endocrine research abs 2 || Hormone and endocrine research abs 3 || Hormone and endocrine research abs 4 || Hormone and endocrine research abs 5 || Follicle and follicular cells research abs 1

Res Reprod. 1972 Jul;4(4):1.
Gonadotrophins and the control of ovulation in women.

[No authors listed]

PIP: Two reports provide comparisons between the levels of plasma hormones (follicle stimulating and luteinizing hormones, FSH and LH) during induced and natural cycles. When the FS preparation (human menopausal gonadotrophin) was administered plasma FSH was elevated in all patients although a subsequent decline occurred in some patients during the last few days of hormonal treatment. Injections of human chorionic gonadotrophin (HHG) for 2 or 3 consecutive days induced a rise in progesterone concentration and a high plasma LH peak that declined a day or so after treatment. Responses to treatment could be influenced by differences in the source of human gonadotrophin (i.e. pituitary or urinary) and by the ratio of FSH to LH in different preparations used to stimulate follicular growth. Enhanced responses were observed when the LH amount was raised and the FSH was maintained at a constant level. Hi gher amounts of urinary estrogen were found with preparations having FSH -LH ratio of approximatley 1:1 than with those of greater than 4:1. The source of gonadotrophin was unimportant. Modification of the treatment in which follicles would first receive initial stimulation followed by declining levels of exogenous hormonal support would induce ovulation. The low incidence of pregnancy indicated a need for further injections of hormones for several days to ensure full follicular enlargement and ovulation.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12306294&dopt=Abstract

Am J Pharm. 1973 July-August;145(4):142-5.
Pharmacology of contraceptive agents - new compounds with new problems?

Sample RG.

PIP: The article is primarily a general discussion of the pill's medical aspects, prefaced by a discussion of the normal human menstrual cycle. Aspects of oral contaceptives reviewed include mechanisms, effectiveness, product formulation, instructions for use, adverse reactions, contraindications, and current developments. Oral contraceptive mechanisms include 1) blockage of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release, 2) alteration of motility in the fallopian tubes 3) modification of endometrial maturation, and 4) rendering the cervical mucus hostile to sperm migration. Mild side effects of various oral contraceptives include nausea, mastalgia, edema, psychological changes, headaches, and failure of withdrawal bleeding. Moderate side effects include breakthrough bleeding, androgenic side effects, patches of increased skin pigmentation, and prolonged amenorrhea and infertility. Severe side effects include impaired liver function and jaundice, hypertension, and thromboembolic disorders. Topics of current research in steroidal contraception include depot therapy, continuous low-dose progestogen therapy, and postcoital estrogen therapy.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12306537&dopt=Abstract

J Clin Endocrinol. 1975;40(5):868-71.
Long-term effects of vasectomy on pituitary-gonadal function in man.

Varma MM, Varma RR, Johanson AJ, Kowarski A, Migeon CJ.

PIP: 16 normal fertile men and 81 men who had been vasectomized 1-5 years previous to the study were examined for plasma concentrations of testosterone (T), follicle-stimulating hormone, luteinizing hormone, and percent binding of T to plasma protein. No significant differences between any of the vasectomy groups and controls could be established for plasma concentrations of any of the hormones measured. Also, no significant difference was observed between the vasectomy groups and controls for the percent binding of T to plasma protein. It appears that vasectomy does not result in abnormal secretions of testosterone and gonadotropins.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12307565&dopt=Abstract

Homemak Mag. 1977 May 3;12(4):33-4.
The pills: oral contraceptives and other hormones.

Kome P.

PIP: There are hormones from 2 sources which determine the menstrual cycle. The pituitary produces luteinizing hormone and follicle stimulating hormone and the ovaries secrete estrogen and progesterone. For clinical use, a cheap source of progesterone has been found in the Mexican yam. Since the 1st oral contraceptives were tested in Puerto Rico in the late 1950s, there has been a trend toward reducing the dosage. Estrogen prevents ovulation in 95-98% of patients. Other factors are also involved. Although it is estimated that 80-100 million women in the world today use oral contraceptives, this method is not always followed for long periods. From 25 to 60% discontinue the use within the 1st year. Increased risk of unfavorable side effects occurs in those with high blood pressure, migraine headaches, diabetes, epilepsy, undiagnosed genital bleeding, or gallbladder disease. Women over age 40 run a greater risk of heart attacks. Intravenous blood clots are the major risk. Severe abdominal, chest, or leg pains, severe headaches, and eye problems may be symptoms of blood clots. With the 21-day package the user takes a pill a day for 3 weeks and then none during menstruation. The sequential type of medication is no longer used. Minipills are taken every day. Missing taking pills is the most common cause of failure of the method. Estrogen replacement therapy for menopausal women is a temporary treatment to relieve physical distress. Depo-Provera, containing a long-acting progesterone agent, may be injected every 3 months instead of daily oral contraceptives. When progesterone is used with an IUD it acts locally. Hormones to maintain pregnancy are no longer used. Use of hormones as a test for pregnancy has been discontinued. Estrogen-progesterone injections given to inhibit milk production may cause serious side effects.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12308626&dopt=Abstract

Dermatol Surg. 2003 Jan;29(1):85-8.
Treatment of trichostasis spinulosa in skin phototypes III, IV, and V with an 800-nm pulsed diode laser.

Manuskiatti W, Tantikun N.

Department of Dermatology, Siriraj Hospital, Mahidol University, Bangkok, Thailand. siwnahidol.ac.th

BACKGROUND. : Trichostasis spinulosa (TS) is a common follicular disorder that results from the retention of multiple vellus hairs within pilosebaceous follicles. A variety of treatment modalities have been used with variable but largely transient success. OBJECTIVES. : To determine whether a pulsed diode laser irradiation would provide a therapeutic response to TS for a prolonged period. METHODS. : Thirteen subjects with untreated TS and skin phototypes III, IV, and V were treated with a 800-nm pulsed diode laser at fluences ranging from 24 to 40 J/cm2 (mean, 36 J/cm2) and a 12- to 20-ms (mean 18 ms) pulse width. Two treatments were delivered at 4-week intervals. Evaluation of improvement was performed at 4 and 20 weeks after the last treatment by a blinded assessment of clinical photographs. RESULTS. : Complete clearing of the lesions was achieved for a period of 8 to 12 weeks. A decrease in dark-plug appearance of greater than 50% was noted in half of the subjects 20 weeks after the second treatment. No pigmentary changes and scarring occurred in any subjects. CONCLUSION. : Pulsed diode laser proved to be a safe and long-term effective treatment for TS in dark-skinned individuals.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12534518&dopt=Abstract

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