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J Small Anim Pract. 1999 Jan;40(1):16-9.
Resolution of paraneoplastic alopecia following surgical removal of a pancreatic carcinoma in a cat.

Tasker S, Griffon DJ, Nuttall TJ, Hill PB.

Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Small Animal Clinic, Summerhall.

A 13-year-old female neutered domestic longhaired cat was presented with a five-month history of progressive weight loss and bilaterally symmetrical alopecia of the ventrum, limbs and perineum. The alopecic skin had a shiny appearance and hair in the non-alopecic areas was easily epilated. Fine needle aspirate cytology of a palpable cranial abdominal mass revealed it to be of epithelial or glandular origin. A pancreatic mass was excised by left pancreatectomy during exploratory laparotomy, and histopathology and skin biopsies confirmed a diagnosis of pancreatic carcinoma with concurrent paraneoplastic alopecia. No evidence of metastases was found on liver and lymph node biopsies. At re-examination 10 weeks after surgery, the hair had fully regrown. Skin signs recurred after 18 weeks and metastatic spread of the tumour was confirmed on postmortem examination. This case confirms that paraneoplastic alopecia associated with internal malignancies is a potentially reversible process if the internal neoplasm is excised.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10092037&dopt=Abstract

Melanoma Res. 2003 Feb;13(1):23-7.
Inverse relationship between density of cutaneous hair and pigmented lesion count in patients with malignant melanoma.

Tobacman JK, Whitaker D, Zimmerman B.

Departments of Internal Medicine and Dermatology, and Biostatistical Consulting Center, University of Iowa, Iowa City, Iowa, USA.

The aim of this study was to investigate whether there is an inverse relationship between the density of cutaneous hair and the number of pigmented lesions in patients with malignant melanoma, and to review the clinical and experimental findings with regard to this relationship. Cutaneous hair density and pigmented lesion counts were determined at nine sites by two physicians using specified criteria in 10 patients with a history of malignant melanoma and 22 control subjects. Study participants were Caucasian males of similar age, height and weight, and had similar occupational, ethnic, socioeconomic and sun exposure backgrounds. Statistical analysis was performed using combined data from all the sites and individual site data to determine whether an inverse relationship between cutaneous hair density and pigmented lesion counts exists. The results demonstrated statistically significant inverse relationships for the chest, upper back, upper arm and forearm in the melanoma patients, but not in the controls. For all the sites combined, both groups demonstrated statistically significant inverse relationships. The study findings are consistent with the hypothesis that some pigmented lesions may arise from the melanocytes of the hair follicle. This hypothesis may lead to new approaches to studying and treating melanoma.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12569281&dopt=Abstract [PubMed - in process]

J Dermatol. 1999 Feb;26(2):98-105.
The potential role of skin protein kinase C isoforms alpha and delta in mouse hair growth induced by diphencyprone-allergic contact dermatitis.

Li LF, Fiedler VC, Kumar R.

Department of Dermatology, University of Illinois at Chicago 60612, USA.

The levels of protein kinase C (PKC) isoforms alpha and delta in mouse hair growth induced by diphencyprone (DPCP)-allergic contact dermatitis (ACD) were studied. BALB/c mice were sensitized by 2% DPCP in acetone on one side of their shaved backs and rechallenged with 0.1% DPCP on the same side weekly for 2 weeks. The opposite side treated with acetone served as a control. Before each elicitation, mice were shaved again in order to observe the hair growth that followed. Enhancement of hair growth on DPCP treated skin was observed in 94% of mice after first elicitation and significant hair growth was shown in all mice after second elicitation. No remarkable hair growth was seen on the control side. Western immunoblot analysis revealed that the level of skin PKC alpha on the DPCP treated side was decreased at 2 and 4 days after sensitization and returned to the control level after first elicitation. At 5 days after the second elicitation, a higher level of PKC alpha was detected. The level of PKC delta remained at the control level and increased at 5 days after second elicitation. These results suggest that: 1) In the first week after sensitization, PKC alpha was down-regulated. This down-regulation may play a role in DPCP-ACD induced hair growth; 2) after the elicitation, PKC alpha was over-expressed and this over-expression was roughly correlated with the enhancement of mouse hair growth, suggesting that over-expression of PKC alpha may also play a part in the proliferation of hair follicle cells; and 3) overexpression of PKC delta after second elicitation may have an inhibitory effect on hair growth that keeps hair growth in balance.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10091479&dopt=Abstract

Acta Otolaryngol Suppl. 1998;539:48-51.
Quantitative immunogold cytochemistry reveals sources of glutamate release in inner ear ischemia.

Matsubara A, Kawabata Y, Takumi Y, Usami S, Shinkawa H, Haruta A, Matsuda K, Tono T.

Department of Otorhinolaryngology, Hirosaki University School of Medicine, Japan. amatsc.hirosaki-u.ac.jp

Glutamate is thought to be a major neurotransmitter between hair cells and afferent dendrites in the inner ear. However, excessive glutamate is known to be excitotoxic, and may be involved in ischemic neuronal damage in the central nervous system. The glutamate concentration in the perilymph has been reported to increase during ischemia, but the source of glutamate is still unclear. In the present study, we have used post-embedding immunogold cytochemistry to analyse changes in the cellular distribution of glutamate in the guinea pig organ of Corti during ischemia. The areal gold particle densities in the inner hair cells of the ischemic side were lower than those of the control side, indicating that glutamate may be released from the hair cells during ischemia. Adjacent supporting cells (border cells) also showed a decrease in particle density, suggesting that they constitute an additional source of glutamate.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10095861&dopt=Abstract

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There are a number of approaches to hair loss problems.
Hair Million is an herbal alternative. It is a formula made of traditional, edible herbs and has been anecdotally demonstrated the efficacy to ward off hair loss problems.

There is no singular medical or alternative cure for hair loss since the biology of hair growth is a highly complicated phenomenon. It is unknown how Hair Million stops hair loss, and promotes hair restoration. The advantages of Hair Million over other approaches are, firstly, Hair Million is comparatively inexpensive, and secondly, it is made only of traditionally used safe and healthy herbs that promote hair growth according to Chinese pharmacopoeia. In addition, Hair Million is cardiotonic, meaning that Hair Million consists of herbs that strengthens your heart, according to Chinese medicine. There is an interesting research paper which correlates baldness to heart diseases: people with alopecia or hair loss problems are significantly more likely to develop heart attacks.

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