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Ophthalmic Epidemiol. 2002 Jul;9(3):153-67.
Risk factors for diabetic retinopathy in the Cree of James Bay.

Maberley DA, King W, Cruess AF, Koushik A.

Department of Ophthalmology, University of British Columbia, Vancouver, B.C., Canada. dmaberlanhosp.bc.ca

BACKGROUND: The purpose of this project was to evaluate risk factors for diabetic retinopathy in the Cree population of James Bay, Ontario. METHODS: A retrospective cohort design was employed. The cohort was made up of all known individuals who had previously been diagnosed with diabetes in the communities of Moose Factory and Moosonee, Ontario. Hypertension, body-mass index, serum lipid levels, renal function status, and hemoglobin A1C were the main exposures of interest. Values for these variables were determined from a retrospective chart review and were sought for each individual for a five-year interval beginning one year following the diagnosis of diabetes. Relative risks for the association of these variables with diabetic retinopathy were determined through both univariate and multivariate Poisson regression. The main outcome of interest in this study was the presence or absence of any diabetic retinopathy in either eye, as determined by a retinal specialist. RESULTS: Significant univariate risks for the development of retinopathy included duration of diabetes, body-mass index, hemoglobin A1C, fasting blood glucose, insulin treatment, and serum cholesterol levels. In multivariate analyses, predictors of diabetic retinopathy included body-mass index, insulin treatment, and serum cholesterol levels. An increase in body-mass index reduced the risk of diabetic retinopathy (Relative Risk [RR] 0.64 per five kg/m( 2), 95% Confidence Interval [CI] 0.04 to 1.00). Insulin therapy was associated with an increased risk of retinopathy when compared to individuals on dietary therapy alone (Relative Risk [RR] 4.71, 95% Confidence Interval [CI] 1.16 to 19.16). For individuals with serum cholesterol levels above the average for the cohort, 5.2 mmol/L, the risk of retinopathy was increased (Relative Risk [RR] 2.38, 95% Confidence Interval [CI] 0.98 to 5.79). INTERPRETATION: Elevated serum cholesterol, lower body-mass index and insulin treatment were all associated with an increased risk of diabetic retinopathy in the Cree of James Bay, Ontario.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12045883&dopt=Abstract

Am J Kidney Dis. 2002 Jun;39(6):1245-54.
Risk factors and risk for mortality of mild hypoparathyroidism in hemodialysis patients.

Guh JY, Chen HC, Chuang HY, Huang SC, Chien LC, Lai YH.

Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Relative hypoparathyroidism (parathyroid hormone [PTH] < or = 200 pg/mL) is prevalent in hemodialysis (HD) patients, with unknown pathogenesis and prognosis. Thus, to clarify risk factors and prognosis of time-dependent relative hypoparathyroidism in HD patients, a retrospective cohort study was performed for 126 HD patients with four or more PTH determinations and no previous total or subtotal parathyroidectomy. Values for intact PTH, ionized calcium, phosphate, magnesium, albumin, creatinine, urea reduction ratio (URR), glucose, hemoglobin A1c (HbA1c), aluminum, and 1,25(OH)2D were obtained at enrollment and at some time during follow-up. The prevalence of relative hypoparathyroidism at entry was 76 of 126 patients (60.3%). Univariate analysis showed that patients with hypoparathyroidism were older, more likely to have diabetes, and had greater ionized calcium levels and lower phosphate, albumin, blood urea nitrogen (BUN), and creatinine levels. Patients with diabetes were older and had a shorter duration of dialysis therapy and lower PTH, phosphate, albumin, BUN, and creatinine levels and URRs. Conversely, multivariate analysis showed that PTH levels at entry were associated directly with creatinine levels and inversely with age and ionized calcium levels (but not diabetes). During follow-up, PTH levels fluctuated concomitantly with ionized calcium and phosphate levels over time in all patients. Time-dependent PTH levels were associated directly with duration of dialysis therapy and use of vitamin D and phosphate and albumin levels, but inversely with age and ionized calcium and magnesium levels (but not glucose or HbA1c levels). Interestingly, time-dependent PTH levels were independently associated with survival after adjusting for traditional risk factors (diabetes, age, albumin and creatinine levels, and URR) and duration of dialysis therapy. We conclude that in HD patients, relative hypoparathyroidism was not associated with diabetes per se. Time-dependent PTH levels were associated with age, duration of dialysis, and levels of ionized calcium, phosphate, albumin, and magnesium. Moreover, relative hypoparathyroidism at entry and lower time-dependent PTH levels predict mortality. 2002 by the National Kidney Foundation, Inc.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12046038&dopt=Abstract

Am J Kidney Dis. 2002 Jun;39(6):1307-9.
Hemodialysis-associated methemoglobinemia in acute renal failure.

DeTorres JP, Strom JA, Jaber BL, Hendra KP.

Division of Pulmonary/Critical Care Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA.

Patients on maintenance hemodialysis are vulnerable to chloramine toxicity if chloramines are inadequately removed. We report two critically ill patients with acute renal failure who developed methemoglobinemia during hemodialysis in the intensive care unit. During the same period, methemoglobin levels measured from 30 patients in the outpatient dialysis facility were undetectable. Methemoglobin levels normalized when the carbon filtration system of the portable dialysis machine was replaced with a larger unit to remove chloramines more effectively. Causes, treatment, and prevention of chloramine toxicity in patients receiving dialysis in the intensive care unit are discussed. 2002 by the National Kidney Foundation, Inc.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12046046&dopt=Abstract

Am J Hematol. 2003 Jan;72(1):67-9.
Cyclosporin A induces erythroid differentiation of K562 cells through p38 MAPK and ERK pathways.

Sawafuji K, Miyakawa Y, Kizaki M, Ikeda Y.

Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

We studied the effects of cyclosporin A (CsA) on the erythroid differentiation of human erythroid leukemia cell line K562. After K562 was treated with CsA for 4 days, the percentage of hemoglobinized cells was increased by 3.3 times. Because it was reported p38 MAPK (p38) and ERK are involved in erythropoietin-induced erythroid differentiation, we studied their roles using specific inhibitors. p38 inhibitor (SB203580) prevented CsA-induced hemoglobin synthesis in K562 cells, although MEK/ERK inhibitor (U0126) enhanced it by 3.3 times in K562 cells. These results indicate activation of p38 and inactivation of ERK are involved in CsA-induced erythroid differentiation of K562 cells. 2002 Wiley-Liss, Inc.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12508271&dopt=Abstract

J Cult Divers. 2002 Spring;9(1):12-22.
Ideal body image and health status in low-income Pacific Islanders.

Wang CY, Abbot L, Goodbody AK, Hui WT.

chenwanawaii.edu

Purpose of this descriptive study was to examine the relationship between ideal body image and family support in Pacific Islander. The subjects were 120 residences (65 with diabetes and 55 without diabetes) of a housing project in Hawaii. Data were collected by interview using the following questionnaires: The Family Behavior Checklist, the Modified Body Image Questionnaire, the Diabetes Knowledge Scale, and demography. Variables of primary interest included the subjects' ideal body image, serum level of glycosylated hemoglobin, hypertension, family support behaviors, ethnicity, and knowledge of diabetes. Findings indicated that the majority of subjects perceived receiving family support in the diet regimen, but not in the areas of glucose self-monitoring, exercise, or medication. The subjects' knowledge level regarding diabetes scored low. Subjects perceived that families lacked knowledge of diabetes. Metabolic control significantly correlated with present age, sources of health insurance, presence of diabetes, and the feeling of ideal body image according to non-Western culture. Subjects had different standards of ideal body image depending on whether they identified with a Western culture or with a non-Western culture. CONCLUSIONS: Presence of hypertension and diabetes were associated multiple environmental factors (e.g. family support, knowledge of diabetes and number of children per household) as well as cultural value (e.g. ideal body image). Findings provide diabetes educators with information regarding the ideal body image among low-income Pacific Islanders. It implies the importance of assessing the individual's perceptions of ideal body image according to his or her cultural values prior to developing regimens for diabetes or hypertension.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12046317&dopt=Abstract

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Hair Loss, or alopecia is a concern for increasing number of folks in aging society. Loss of hair is a visible problem, and affects the appearance and changes identity of a person.
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Hair growth is a sophisticated biological process, which has not yet been completely understood. A multitude of therapeutic measures, including drugs, surgery, and suppelements have been made available, and used. However, due to the heterogeneity in the underlying cause, there is no perfect cure for all hair loss cases. Most of chemical drugs and hair transplantation surgeries are not free from varying degrees of undesirable side effects on health.

Hair Million is an alternative solution to hair loss problems. Anecdotally, it shows prositive results and improvement for age-related hair thinning and hair loss for a fraction of people who take it. We do not know the mechanisms of action as to how Hair Million works to help stop hair loss, and promote hair growth. We only know by anecdotal observations. There has been no clinical trials nor placebo controlled statistical analysis on the efficacy of Hair Million on hair loss and hair growth. However, there are two merits in this hair restoration herbal formula:
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