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Pathogen research abs 1 || Pathogen research abs 2 || Pathogen research abs 3 || Pathogen research abs 4 || Pathogen research abs 5 || Hormone and endocrine research abs 1 || Hormone and endocrine research abs 2 || Hormone and endocrine research abs 3 || Hormone and endocrine research abs 4 || Hormone and endocrine research abs 5

Biol Reprod. 1999 May;60(5):1120-7.
Intrafollicular content of luteinizing hormone receptor, alpha-inhibin, and aromatase in relation to follicular growth, estrous cycle stage, and oocyte competence for in vitro maturation in the mare.

Goudet G, Belin F, Bezard J, Gerard N.

I.N.R.A.-Haras Nationaux, Reproduction Equine, P.R.M.D., F-37380 Nouzilly, France.

The intrafollicular content of LH receptor, alpha-inhibin, and aromatase are known good indicators of follicular status. We investigated the amounts of these proteins in granulosa and cumulus cells in relation to oocyte competence for in vitro maturation, follicular growth, and estrous cycle stage in the mare. Follicular punctures were performed 34 h after an injection of crude equine gonadotropins, either during the follicular phase, at the end of the follicular phase, or during the luteal phase. The cumulus-oocyte complex, granulosa cells, and follicular fluid of follicles larger than 5 mm were collected. The nuclear stage of the oocytes after in vitro culture was determined microscopically. Granulosa and cumulus cell amounts of LH receptor, alpha-inhibin, and aromatase were assessed by the semiquantitative Western blot method and image analysis. Follicular fluids were assayed for progesterone (P4) and estradiol-17beta (E2). The three factors were expressed in mural granulosa and cumulus cells from all follicles from the gonadotropin-independent growth period until the preovulatory stage. Considering all the follicles punctured, the amounts of LH receptor and alpha-inhibin in granulosa cells were not different for the three physiological stages studied. The amounts of aromatase in granulosa cells, as well as the E2:P4 ratios, were higher for follicles punctured during the follicular phase than for the two other groups (p < 0.05). Considering the data from the three groups, the E2:P4 ratio and the LH receptor and aromatase contents, but not alpha-inhibin, in granulosa cells increased with an increase in follicular diameter (p < 0.01). The E2:P4 ratios and the amounts of LH receptor, alpha-inhibin, and aromatase in granulosa cells were lower in follicles 5-9 mm in diameter than in larger ones (p < 0.05). In cumulus cells, the amounts of the three factors were different neither between the three groups nor between the follicular diameters. Although we could not establish any obvious relationship to oocyte competence for in vitro maturation, the influence of the follicle diameter on the content of LH receptors, alpha-inhibin, and aromatase in granulosa cells was similar to the influence of follicle diameter on oocyte competence. Therefore, one can hypothesize that, in the mare, there is a link between the acquisition of oocyte competence and the expression of these factors in the follicular cells.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10208973&dopt=Abstract

J Br Menopause Soc. 2003 Mar;9(1):22-6.
Learning disabilities and the menopause.

Martin DM, Kakumani S, Martin MS, Cassidy G.

Clinical Audit Co-Ordinator, Brooklands, Coleshill Road, Marston Green, Birmingham.

How menopause affects women with learning disabilities is a neglected area of research. Women with learning disabilities experience the same physiological effects of the menopause as others, including hot flushes and night sweats, but difficulties in understanding and communication mean that additional supports are often required. They are less likely to report the psychological difficulties or symptoms associated with menopause than women in the general population. Menopause is usually earlier in women with learning disability and earlier still for those with Down's syndrome. Debate about hormone replacement therapy often ignores the needs of women with learning disabilities who, as a result, are very often excluded from the decision-making process. Physical problems among women with learning disabilities and other aspects of ageing warrant particular focus.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12804309&dopt=Abstract [PubMed - in process]

J Br Menopause Soc. 2003 Mar;9(1):32-5.
The use of food supplements among women attending menopause clinics in the West Midlands.

Gokhale L, Sturdee DW, Parsons AD.

Specialist Registrar, Derriford Hospital, Plymouth, Devon.

OBJECTIVE: To estimate the extent of use of over the counter food supplements in women attending menopause clinics in the West Midlands. Study design: Questionnaire survey of women attending menopause clinics in Solihull Hospital, Birmingham Heartlands Hospital, Rugby and Walsgrave Hospitals and Birmingham Women's Hospital. MAIN OUTCOME MEASURES: Type and rate of use of food supplements in hormone replacement therapy (HRT) users and nonusers and perceived benefits. RESULTS: Three hundred and forty women completed the questionnaire. 95% (n = 326) belonged to the white European ethnic group. The median age was 53 years, with 50% (n = 170) in the 50-59 years age group, and 30 % (n = 95) in the age range 40-49 years. Overall use of over the counter supplements in the clinic was 43% (n = 147), with Oil of Evening Primrose (53%) and vitamins (44%) being the most commonly used preparations. 71% (n = 242) women were users of conventional HRT. Of these, 46% were also using food supplements. The use of food supplements was higher amongst HRT users (46%) as compared to non-HRT users (32%). The use was similar between smokers and non-smokers. The most commonly perceived benefit was a feeling of well-being, 39% (n = 58/147). The proportionate use was highest in social class I and class II (51% and 54% respectively), in keeping with amount of disposable income. Friends (27%), the internet (26%) and magazines (20%) were the most commonly quoted sources of information. 79% (n = 116/147) were spending up to 10 each month on alternative remedies. 10% (n = 14/147) of women were visiting practitioners of alternative remedies. CONCLUSIONS: The use of food supplements is widespread and particularly in those already taking conventional HRT. This study was not designed to test confidence in orthodox medicine, but the prevalence of use of supplements amongst menopausal women attending menopause clinics. The most commonly perceived benefit is a feeling of well-being, but users of food supplements are unsure of any additional benefit when supplements are taken in conjunction with conventional therapy. There is a misapprehension that "herbal" or "natural" equals safe. In addition, the correlation between supplement use and side effects is very seldom made, as these compounds are mistakenly considered almost universally safe, and physicians often fail to enquire about their use in routine history taking.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12804311&dopt=Abstract [PubMed - in process]

J Br Menopause Soc. 2002 Dec;8(4):137-40.
Changes in body composition at menopause-age, lifestyle or hormone deficiency?

Sorensen MB.

Cardiovascular MR Unit, Royal Brompton Hospital, Imperial College School of Medicine, London SW3 6NP, UK.

One of the major concerns of perimenopausal women is obesity-and for a good reason. Both general and abdominal obesity as well as loss of skeletal muscle (sarcopenia) are accelerated through the menopausal transition and lifestyle changes as well as sex hormone deficiency play important roles. Most well conducted clinical trials have demonstrated hormone replacement therapy induced reversal or at least impairment of menopausal changes in body composition and the common worry that it causes weight gain is unsubstantiated. Coaching of weight loss in obese individuals is often a frustrating task but is nevertheless of immense importance because of the health hazards of obesity. Through the climacteric period, short-term hormone replacement therapy, with or without androgens for preservation of muscle mass, might inhibit obesity and this is likely to boost motivation for introduction of more comprehensive and long-lasting initiatives linked to persistent weight loss and long-term health benefit.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12804321&dopt=Abstract [PubMed]

J Br Menopause Soc. 2002 Dec;8(4):141-6.
Statins and menopausal health.

Mueck AO, Seeger H.

Department of Obstetrics and Gynaecology, University of Tuebingen, Calwerstrasse 7, 72 076 Tuebingen, Germany.

Cardiovascular disease is associated with high morbidity and mortality. Cholesterol-lowering statins can reduce health risks both in men and women. While this benefit has thus far been attributed to the lipid-lowering effects of these drugs, the importance of their direct actions on vascular tissue is gaining more recognition. Furthermore, recent studies suggest that statins might also be effective in preventing osteoporosis and Alzheimer's disease. Equally interesting are experimental results showing that statins may inhibit growth of certain malignancies such as the breast. When statins are combined with hormone replacement therapy (HRT), even greater beneficial effects on the lipid profile can be obtained. To our knowledge we have investigated for the first time direct vascular effects by combining statins with HRT. We were able to identify significant beneficial effects on endothelial function and vascular smooth muscle proliferation. In the context of current discussions on the benefits and risks of HRT in treating patients with pre-existing cardiovascular disease, it appears particularly important that interventional studies should be conducted to evaluate the therapeutic relevance of statin/HRT combinations. At present, this is the most important conclusion drawn from the data collected thus far on the combination of these two drug types. There is some evidence suggesting drug-specific effects, particularly adverse reactions and statin interactions, which should be considered when using this combination therapy.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12804322&dopt=Abstract [PubMed]

Loss of hair changes the appearance of a person, and the identity of the person in social context to a certain extent. Hair growth is a complex biological process, which has not yet been completely understood. A multitude of therapeutic measures, including drugs, surgery, and suppelements have been made available, and used. However, due to the diversity of the problems underlying hair loss, there is no single solution for all hair loss cases. Most of chemical drugs and hair transplantation surgeries are not free from varying degrees of undesirable side effects on health.

Hair Million is an alternative solution to hair loss problems. Albeit only anecdotally, it has demonstrated efficacy in the improvement for age-related hair thinning and hair loss for a significant fraction of people who take it as recommended. We do not know the mechanisms of action as to how Hair Million works to help stop hair loss, and promote hair growth. We only know by anecdotal observations. There has been no clinical trials nor placebo controlled statistical analysis.

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