DreamPharm Products:
Lutein-20||Herbs for headache, fever, and migraine ||
Milk thistle||Saw palmetto||
Triple B Super Vision||Garlic, Ginger, and Grapeseed Extract||
Ginseng and Ginkgo||Hair Million||
DHEA||Coenzyme Q10||
Sleep Aid herbal formula - natural sleep aid||Herbal Breath - herbs for bad breath problems.||
Weight loss herbal formula for menopause and pms||Ginkgo biloba||
Colon cleansing, Laxative||ViaVita, Lecithin for healthy liver
Fatty acids resources:
Pathogen research abs 1 || Pathogen research abs 2 || Pathogen research abs 3 || Pathogen research abs 4 || Pathogen research abs 5 ||
Hormone and endocrine research abs 1 || Hormone and endocrine research abs 2 || Hormone and endocrine research abs 3 || Hormone and endocrine research abs 4 || Hormone and endocrine research abs 5
Anim Reprod Sci. 2003 Oct 15;78(3-4):271-87.
The pattern and manipulation of ovarian follicular growth in goats.
Rubianes E, Menchaca A.
Department of Animal Production, Faculty of Agriculture, Universidad de la Republica, Garzon 780, Montevideo, Uruguay
The understanding of the dynamics and regulation of follicle development in the goat has increased in recent years due to the use of ultrasonography. Previous findings observed in other ruminants extend to this species such as: the wavelike pattern of follicular growth with waves emerging every 5-7 days; the presence of follicular dominance, particularly during wave 1 and the ovulatory wave; and the role of progesterone concentrations on follicular wave turnover. However, traditional hormone treatments for oestrus synchronisation and superovulatory programs remain essentially unmodified and without taking into account this new information. The use of long progestogen priming is largely unjustified. Short progestogen priming can be used successfully in both anoestrous and cycling goats (in this case associated with PGF2alpha), and also linked with timed artificial insemination. On the other hand, recent attempts to overcome the deleterious effect of the dominant follicle on superovulatory response using the emergence of the wave 1 have been successful. Overall, using ultrasonography a new field has been opened and surely successful output will be forthcoming in the next years to improve reproductive management of the goat, the fastest growing ruminant population in the world.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12818649&dopt=Abstract [PubMed - in process]
Anim Reprod Sci. 2003 Oct 15;78(3-4):327-44.
Associations between the manipulation of patterns of follicular development and fertility in cattle.
Macmillan KL, Segwagwe BV, Pino CS.
Department of Veterinary Science, University of Melbourne, 250 Princes Highway, Vic. 3030, Werribee, Australia
The wave-like patterns of ovarian follicular development in cattle can be manipulated by shortening the luteal phase with prostaglandin F(2alpha) (PGF), lengthening the period of follicle dominance with progesterone or curtailing follicle development with GnRH or oestradiol as 17beta, benzoate or cypionate. These hormones can also be used to synchronise ovulation allowing timed inseminations without detected oestrus. Progesterone, PGF, GnRH and oestradiol benzoate have each been used to increase conception rates in some situations, but their use has reduced them in others. For example, inseminations made within 96h of a single injection of PGF administered during the luteal phase were associated with increased conception rates in dairy cows whereas double injection protocols reduced conception rates.The three forms of oestradiol and GnRH have greater effects on follicular development following divergence and dominance than following wave emergence. This can mean that follicles of differing maturity will be present about 7 days later and can result in varied intervals to the onset of oestrus following a PGF injection. The consequent variation in ovulation time can be reduced by injecting GnRH or an oestradiol during pro-oestrus. This means that some less mature follicles will ovulate, forming corpus luteum (CL) associated with a slower rise in plasma progesterone and lower mid-luteal concentrations. The lower conception rates recorded with single timed inseminations with synchronised ovulations have been associated with increased prevalences of short cycles in lactating dairy cows (with GnRH), with long luteal phases in cows and heifers (with oestradiol benzoate) and with embryo loss following positive pregnancy diagnosis (as with Ovsynch in lactating Holstein cows). Extensive Canadian studies have demonstrated that these same hormones can be successfully used without these limitations and reliably obtaining conception rates over 50% and up to 70% in beef cattle that have been supplemented with a progestin during the period of ovarian follicle synchronisation.The inherently lower fertility of Holstein cows during early lactation may be contributing to the reduced effectiveness of hormonal treatments for synchronised follicle development and ovulation. The role of reduced dose rates of GnRH in compromising this effectiveness needs to be determined if the potential of these treatments realised with beef cattle is to be achieved with lactating Holstein cows.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12818652&dopt=Abstract [PubMed - in process]
Anim Reprod Sci. 2003 Oct 15;78(3-4):345-70.
Effects of nutrition and metabolic status on circulating hormones and ovarian follicle development in cattle.
Diskin MG, Mackey DR, Roche JF, Sreenan JM.
Animal Reproduction Department, Teagasc, Athenry, Co. Galway, Ireland
Nutrition is a major factor affecting cow reproductive efficiency. Long-term moderate or chronic dietary restriction results in a gradual reduction in dominant follicle (DF) growth rate, maximum diameter and persistence. Animals become anoestrus when they lose on average 22-24% of their initial body weight. There is evidence of significant animal-to-animal variation in the interval from the imposition of dietary restriction to onset of anoestrus and from the recommencement of re-alimentation to resumption of ovulation. In contrast, acute dietary restriction to 40% of maintenance requirements rapidly reduces dominant follicle growth rate and maximum diameter and induces anoestrus in a high proportion (60%) of heifers within 13-15 days of dietary restriction. In lactating dairy and beef cows negative energy balance or reduced dietary intake in the early post-partum period, while not affecting the population of small-to-medium size follicles, adversely affects the size and ovulatory fate of the dominant follicle. Re-alimentation of nutritionally induced anoestrous heifers results in an initial gradual increase in dominant follicle growth rate and maximum diameter, followed by a more accelerated increase in dominant follicle growth rate and maximum diameter as the time of resumption of ovulation approaches. Increased dominant follicle growth rate and maximum diameter are associated with increased peripheral concentrations of IGF-I, pulsatile LH and oestradiol. Direct nutritional effects on ovarian function appear to operate through hepatic rather than follicular regulation of IGF-I, and on systemic concentrations of IGF-I BPs and insulin; cumulatively reducing follicular responsiveness to LH and ultimately shutting down follicular oestradiol production. Indirect nutritional effects are apparently mediated through altering the GnRH pulse generator and in-turn selectively reducing pulsatile LH secretion without any apparent adverse effect on FSH secretory patterns. Endogenous opioid peptides, NPY and glucose appear to play a role in the nutritional regulation of GnRH release and in turn pulsatile LH secretion.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12818653&dopt=Abstract [PubMed - in process]
Eur J Pharmacol. 2003 Jun 20;471(2):77-84.
Positive regulation of GABA(B) receptors dually coupled to cyclic AMP by the allosteric agent CGP7930.
Onali P, Mascia FM, Olianas MC.
Section of Biochemical Pharmacology, Department of Neuroscience, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Cagliari, Italy. onalnica.it
The ability of 2,6 Di-tert-butyl-4-(-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930), a positive allosteric modulator of GABA(B) receptors, to regulate GABA(B) receptor-induced stimulation and inhibition of adenylyl cyclase activity in rat brain was investigated. In olfactory bulb granule cell layer and in frontal cortex, CGP7930 potentiated the stimulatory effects of (-)-baclofen and gamma-aminobutyric acid (GABA) on basal and corticotropin-releasing hormone-stimulated adenylyl cyclase activities, respectively. In these stimulatory responses, CGP7930 enhanced both agonist potencies and maximal effects. When GABA(B) receptor-mediated inhibition of forskolin-stimulated adenylyl cyclase activity of frontal cortex was examined, CGP7930 increased the agonist potencies but failed to affect the maximal effect of (-)-baclofen and modestly increased that of GABA. Similar results were obtained for the inhibition of Ca(2+)/calmodulin-stimulated adenylyl cyclase in striatum and cerebellum. Western blot analysis of each membrane preparation showed the presence of GABA(B2) receptor subunit, a putative site of action of CGP7930. These data indicate that CGP7930 positively modulates brain GABA(B) receptors coupled to either stimulation or inhibition of cyclic AMP signalling.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12818694&dopt=Abstract [PubMed - in process]
Am J Pathol. 2003 Jul;163(1):37-45.
Methylation target array for rapid analysis of CpG island hypermethylation in multiple tissue genomes.
Chen CM, Chen HL, Hsiau TH, Hsiau AH, Shi H, Brock GJ, Wei SH, Caldwell CW, Yan PS, Huang TH.
Department of Life Sciences, National Chung Hsing University, Taiwan, Republic of China.
Hypermethylation of multiple CpG islands is a common event in cancer. To assess the prognostic values of this epigenetic alteration, we developed Methylation Target Array (MTA), derived from the concept of tissue microarray, for simultaneous analysis of DNA hypermethylation in hundreds of tissue genomes. In MTA, linker-ligated CpG island fragments were digested with methylation-sensitive endonucleases and amplified with flanking primers. A panel of 468 MTA amplicons, which represented the whole repertoire of methylated CpG islands in 93 breast tumors, 20 normal breast tissues, and 4 breast cancer cell lines, were arrayed on nylon membrane for probe hybridization. Positive hybridization signals detected in tumor amplicons, but not in normal amplicons, were indicative of aberrant hypermethylation in tumor samples. This is attributed to aberrant sites that were protected from methylation-sensitive restriction and were amplified by PCR in tumor samples, while the same sites were restricted and could not be amplified in normal samples. Hypermethylation frequencies of the 10 genes tested in breast tumors and cancer cell lines were 60% for GPC3, 58% for RASSF1A, 32% for 3OST3B, 30% for HOXA5, 28% for uPA, 25% for WT1, 23% for BRCA1, 9% for DAPK1, and 0% for KL. Furthermore, hypermethylation of 5 to 7 loci of these genes was significantly correlated with hormone receptor status, clinical stages, and ages at diagnosis of the patients analyzed. This novel approach thus provides an additional avenue for assessing clinicopathological consequences of DNA hypermethylation in breast cancer.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12819009&dopt=Abstract
Is your hair shedding prematurely? Are you losing hair gradually or all of a sudden, or just as you are aging?
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Numerous anecdotal cases, and personal testimonies indicate that this herbal formula based on Chinese herbs actually
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DHEA has been suggested to provide numerous potential benefits. DHEA (or dehydroepiandrosterone) is converted into androgens (male hormones)
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DreamPharm Online Healthy Supplements ||
Constipation relief, laxative, colon cleansing ||
Lutein ||
Progesterone Cream ||
Natural herbal formula for hair loss problems ||