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Pathogen research abs 1 || Pathogen research abs 2 || Pathogen research abs 3 || Pathogen research abs 4 || Pathogen research abs 5 || Hormone and endocrine research abs 1 || Hormone and endocrine research abs 2 || Hormone and endocrine research abs 3 || Hormone and endocrine research abs 4 || Hormone and endocrine research abs 5

Toxicology. 1979 Dec;15(1):19-29.
Heroin addiction: relationship between the plasma levels of testosterone, dihydrotestosterone, androstenedione, LH, FSH, and the plasma concentration of heroin.

Bolelli G, Lafisca S, Flamigni C, Lodi S, Franceschetti F, Filicori M, Mosca R.

Changes in sexual function and hormone levels are commonly found in subjects addicted to narcotics. In this study we examined 16 male and 3 female addicts who had been taking heroin (H) in the last year in doses higher than 150 mg/day. In these patients, who presented similar clinical problems, we assayed by RIA the plasma levels of heroin, testosterone, (T), dihydrotestosterone (DHT), androstenedione (A), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) for periods of 150 min, 6 h and 9 h. We found a significant reduction of T and DHT concomitant with higher plasma concentrations of heroin but no relevant changes of A, LH and FSH. T and DHT returned to the initial levels after the decrease of heroin concentration. The GnRH test effectd on a female subject allowed us to make the diagnosis of hypothalamic amenorrhea. In the same patient no circadian rhythms for T, DHT and A were detected.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=120622&dopt=Abstract

C R Seances Acad Sci D. 1979 Dec 17;289(16):1319-22.
[Effect of progesterone on male and female sex behavior induced by steroid hormones in adult ovariectomized ewes]

[Article in French]

Fabre-Nys C.

Ovariectomized adult Ewes daily treated with I/M injections of testosterone propionate (10 mg/day) or oestradiol benzoate (200 microgram/day) show male-like sexual behaviour and simultaneously a permanent female receptivity. Additional daily treatment with 100 mg of progresterone results in a rapid decrease in male sexual responses both when Ewes are treated with testosterone and with oestradiol. No effect is observed on the female receptivity. Cyproterone acetate (100 mg/day) given to Ewes in addition to daily injection of testosterone propionate (10 mg/day) has effects similar to those of progesterone. These results show that progesterone has antiandrogen and antioestrogen properties and that this hormone administered at high doses is able to inhibit male activity.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=120792&dopt=Abstract

Ric Clin Lab. 1979 Oct-Dec;9(4):413-8.
Prolactin secretion and nodular goiter. (Hypothetical correlations).

Valenti G, Volpi R, Battistini C, Vescovi PP, Sacco M, Chiodera P, Zanella E, Butturini U.

In a group of 129 female patients with nodular goiter, Graves' disease and primary hypothyroidism, the PRL and TSH secretions were studied in parallel. Concurrent changes in the two hormones were evident only in conditions of marked hyper- or hypothyroidism. In the patients with non-toxic nodular (single or multiple) goiter the TSH showed low or normal values, while the PRL appeared normal or elevated. From these results two important conclusions can be drawn: 1. the T3 and T4 levels interact with PRL secretion concomitantly with TSH only when they undergo a huge deviation from the normal range; 2. the goitrogenic action of PRL that has been reported in experimental animals cannot be excluded in man.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=120979&dopt=Abstract

Acta Eur Fertil. 1979 Mar;10(1):29-33.
The ultradian pulsatile release of gonadotropins in normal female subjects.

Filicori M, Bolelli G, Franceschetti F, Lafisca S.

With an original statistical study which employes the analysis of variance and the harmonic analysis, the authors evaluated the levels of LH and FSH obtained from 5 female patients of the infertility clinic. These subjects, apparently free from endocrine disorders, underwent a 7-hour test consisting of samples obtained at 20 minute intervals. By a double-antibody RIA method, we assayed LH and FSH in quintuplicate or triplicate in each sample and counted the tubes twice consecutively. In all subjects for LH and in 3 subjects for FSH we detected a real ultradian pulsatile release of the hormone. Period and amplitude of the LH fluctuations vary according to the phase of the menstrual cycle (follicular phase: short period and low amplitude; luteal phase: long period and high amplitude). No change in amplitude was observed for FSH, while the period in two cases varied in accordance with LH. In two cases we found multiple periods in the fluctuations of one hormone during the same test.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=121012&dopt=Abstract

Endokrinologie. 1979;74(3):287-96.
The effect of estrogen withdrawal upon the tubal epithelium of immature ovariectomized rhesus monkey (Macaca mulatta) pretreated with estradiol dipropionate.

Pathak RK, Bajpai VK, Shipstone AC, Karkun JN.

Immature ovariectomized rhesus monkey (Macaca mulatta) were injected intramuscuarly with estradiol dipropionate (EDP) at a dose of 20 micrograms/kg/day for 6 consecutive days and were sacrificed at days 1, 3, 8, 13 and 25 following withdrawal of the hormone. The overall height of the epithelia of the infundibulum (Inf), Ampulla (A) and the isthmus (I) and the status of the ciliated and nonciliated cells therein were observed under both the light and electron microscope and those observed at days 3-25 were assessed against those found at day 1 (control values). The EDP effect on the above aspects did not change significantly at days 3 and 8 as compared to day 1. There was rather an increase of such hormone impact on day 8: this is indicated by the observations that the nonciliated cells possessed a greater number of secretory granules (SG) and/or exhibited signs of higher secretory activity. Possible neosynthesis of SG was discerned on days 3 and 8. Retrogressive changes in the epithelia and in the constituent cell types were evident on day 13; those advanced further on day 25 but to different degrees in different segments. The changes were highest in Inf following by those in A and I in order: Inf greater than A greater than I. All these changes were described and commented upon. It is concluded that the estrogen impact lasts for some time after its withdrawal and that the nature of subsequent regression of any epithelium and of the celltype therein is determined by their position within the tube.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=121075&dopt=Abstract

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