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Fatty acids resources:

Pathogen research abs 1 || Pathogen research abs 2 || Pathogen research abs 3 || Pathogen research abs 4 || Pathogen research abs 5 || Hormone and endocrine research abs 1 || Hormone and endocrine research abs 2 || Hormone and endocrine research abs 3 || Hormone and endocrine research abs 4 || Hormone and endocrine research abs 5





Bioorg Khim. 2002 May-Jun;28(3):251-7.
[Species and tissue distribution specificity of proteins binding 16alpha,17alpha-cycloalkane derivatives of progesterone]

[Article in Russian]

Smirnov AN, Pokrovskaia EV, Shevchenko VP, Nagaev IIu, Miasoedov NF, Levina IS, Kulikova LE, Kamernitskii AV.

Biological Faculty, Moscow State University, Vorob'evy gory, Moscow, 119899 Russia. smirnov_aail.ru

The binding of [3H]progesterone and [3H] 16 alpha,17 alpha-cycloalkanoprogesterones to proteins from rat, rabbit, and human uteri and other organs was studied. We found that 16 alpha,17 alpha-cycloalkanoprogesterone derivatives display affinities for the uterine progesterone receptors comparable with that of the natural hormone and no substantial species differences in the affinity. Rabbit uterus was found to have no proteins distinct from the progesterone receptor that specifically bind [3H] 16 alpha,17 alpha-cycloalkanoprogesterones. At the same time, in the human uterus, we found another protein that binds some of these progesterone derivatives; it turned out to be similar to the protein from rat uterus. A similar protein with the same selectivity and affinity for steroids was also found in rat and human kidneys. Blood serum, liver, lung, and a number of other tissues were found to contain a protein of the third type that binds the same 16 alpha,17 alpha-cycloalkanoprogesterones and exhibits submicromolar Kd values for these steroids and a very low affinity for progesterone. We speculated that the introduction of a bulky substituent adjacently to the 17 beta-side chain of progesterone could result in a change in the general biodynamics of the derivative including its transport, uptake, and accumulation in tissues, which may determine the selectivity of its effect.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12077851&dopt=Abstract



Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1998;16(4):251-5.
Effect of testosterone on Leishmania donovani infection levels of murine bone marrow derived-macrophages.

Yin G, Guo Z, Yin L, Zhao J, Qiao Z, Frank W.

Division of Parasitology of Shanxi Medical University, Taiyuan 030001.

AIM: To investigate the effect of the male sex hormone, testosterone (Te), on Leishmania donovani infection levels of bone marrow derived macrophages(BMMs) from female mice of strain C57BL/6J. METHODS: After three weeks of Te-treatment, the BMMs were isolated, challenged with L. donovani at a ratio of 10 to 1 promastigotes per macrophage, and the infection levels of different time points were monitored by Giemsa staining. RESULTS: BMMs from Te-treated mice had a significantly increased initial uptake(3 h post infection, P < 0.05) of promastigotes and carried heavier infection levels at all time points(24 h, 48 h, 72 h post infection, P < 0.01), compared with those from oil treated controls. CONCLUSION: Te can increase L. donovani infection levels of BMMs, being possibly related to Te-induced immunosuppression.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12078252&dopt=Abstract



Qual Saf Health Care. 2002 Mar;11(1):32-8; discussion 38-9.
Development and preliminary evaluation of a clinical guidance programme for the decision about prophylactic oophorectomy in women undergoing a hysterectomy.

Pell I, Dowie J, Clarke A, Kennedy A, Bhavnani V.

Environmental Epidemiology Unit, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.

OBJECTIVES: To develop a decision analysis based and computerised clinical guidance programme (CGP) that provides patient specific guidance on the decision whether or not to undergo a prophylactic oophorectomy to reduce the risk of subsequent ovarian cancer and to undertake a preliminary pilot and evaluation. SUBJECTS: Women who had already agreed to have a hysterectomy who otherwise had no ovarian pathology. SETTING: Oophorectomy decision consultation at the outpatient or pre-admission clinic. METHODS: A CGP was developed with advice from gynaecologists and patient groups, incorporating a set of Markov models within a decision analytical framework to evaluate the benefits of undergoing a prophylactic oophorectomy or not on the basis of quality adjusted life expectancy, life expectancy, and for varying durations of hormone replacement therapy. Sensitivity analysis and preliminary testing of the CGP were undertaken to compare its overall performance with established guidelines and practice. A small convenience sample of women invited to use the CGP were interviewed, the interviews were taped and transcribed, and a thematic analysis was undertaken. RESULTS: The run time of the programme was 20 minutes, depending on the use of opt outs to default values. The CGP functioned well in preliminary testing. Women were able to use the programme and expressed overall satisfaction with it. Some had reservations about the computerised formal and some were surprised at the specificity of the guidance given. CONCLUSIONS: A CGP can be developed for a complex healthcare decision. It can give evidence-based health guidance which can be adjusted to account for individual risk factors and reflects a patient's own values and preferences concerning health outcomes. Future decision aids and support systems need to be developed and evaluated in a way which takes account of the variation in patients' preferences for inclusion in the decision making process.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12078367&dopt=Abstract



osu.edu

PURPOSE: To examine college students' understanding of safer sexual encounters, including expectation for sexual activities, planning for sexual encounters, and ideas about what constitutes "safe" sex. DESIGN: Exploratory design of college students' perceptions of and actual sexual activities that occurred in their last or most memorable sexual encounter. METHODS: Participants in one U.S. university completed three open- and closed-ended questions about their activities, as part of a larger questionnaire concerning contextual factors in their sexual encounters. A content analysis was conducted on data from open-ended questions. Encounters were categorized by risk for further analysis. FINDINGS: No significant differences were found in expectations regarding sexual activities between participants who had risky and safer encounters, except that participants who had safer encounters expected touching through clothing significantly less than did those who had risky encounters. Frequencies of sexual activities varied greatly between the two risk groups. No differences were found between the two groups concerning whether the encounter was planned or in expectation of sexual activities by planning of the encounter. The majority erroneously thought they had "safer" sex. The most reported reasons for believing a risky encounter was safer included the use of a hormone-based birth control method, use of a condom during vaginal sex only, and believing no sex had occurred in the case of oral sex. CONCLUSIONS: For these participants, planning of the encounter was not related to safer sexual activities and safer sexual activities were generally misunderstood.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12078537&dopt=Abstract



J Anim Sci. 2002 Jun;80(6):1545-55.
Growth performance and metabolic and endocrine traits in calves pair-fed by bucket or by automate starting in the neonatal period.

Nussbaum A, Schiessler G, Hammon HM, Blum JW.

Division of Animal Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing, Faculty of Veterinary Medicine, University of Berne, Switzerland.

Effects of different feeding frequencies on growth performance, preprandial metabolic parameters, and endocrine traits were studied in calves up to 28 d after birth and respective postprandial changes were investigated on d 3 and 7. Calves were fed with a computer-programmed automate that allowed frequent daily intakes (GrA; n = 7) or were fed twice daily by bucket (GrB; n = 7) the same daily amounts (pair-feeding) of colostrum and milk. Weight gains did not differ significantly between groups. Plasma protein was higher (P < 0.01) from d 14 to 28 in GrB than in GrA. Plasma glucose increased postprandially in GrB on d 3 and 7 but in GrA only on d 3, and there was a significant treatment x time interaction on d 3 and 7 after feed intake. For plasma triglycerides there was a significant postprandial treatment x time interaction on d 3, and triglycerides were higher (P < 0.05) in GrA than in GrB before feed intake on d 7. For insulin concentrations on d 7 the treatment x time interaction was significant and concentrations 8 h after feed intake were higher (P < 0.05) in GrA than GrB. For concentrations of growth hormone on d 7 during an 8-h period the treatment x time interaction was significant and concentrations from 320 to 340 min after feed intake were higher (P < 0.05) in GrB than in GrA. Plasma IGF-I concentrations were higher (P < 0.05) in GrA than in GrB on d 7. The hematocrit and concentrations of immunoglobulin G, albumin, urea, creatinine, L-lactate, nonesterified fatty acids, cholesterol, glucagon, and thyroxine did not differ between groups. In conclusion, feed intake at high frequency by an automate transiently changed some metabolic and endocrine traits (glucose, triglyceride, insulin, and IGF-I) but had no significant effects on growth performance during the first 4 wk of life.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12078736&dopt=Abstract







Prescription drugs, surgical hair transplantation, topical application of various oils or creams... Also prayer and wishing...
Hair Million is an alternative approach to hair loss problems. Anecdotes and personal experiences testify that it works. Hair Million shows positive results and improvement for age-related hair thinning and hair loss for a large fraction of people who take it. How does it work? Good question. The molecular biological or clinical mechanisms of action as to how Hair Million exactly works to help stop hair loss, and promote hair growth is completely unknown. The only evidences for the effecacy of Hair Million on hair growth are only anedotal and based on personal experiences. There has been no clinical trials or placebo controlled statistical analysis on the efficacy of Hair Million on hair loss and hair growth.
That's enough for many people. Also, there are two merits in the hair restoration herbal formula:
Firstly, HairMillion is comparatively inexpensive, and secondly, it is made only of herbs that are known to be safe when consumed in regular quantities. Herbs in Hair Million are also known for cardiotonic effects, meaning that the herbs will make your heart stronger.












DHEA is a natural hormone, and it is produced in our body by the adrenal glands. DHEA has been suggested to provide numerous potential benefits. DHEA (or dehydroepiandrosterone) is converted into androgens (male hormones) or estrogens (female hormones) in the cells.





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