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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs

Arch Pediatr Adolesc Med. 2003 Jul;157(7):661-4.
Safety of polyethylene glycol 3350 for the treatment of chronic constipation in children.

Pashankar DS, Loening-Baucke V, Bishop WP.

Division of Gastroenterology, Department of Pediatrics, University of Iowa, Iowa City 52242, USA. Dinesh-Pashankaiowa.edu

OBJECTIVES: To assess the clinical and biochemical safety profile of long-term polyethylene glycol 3350 (PEG) therapy in children with chronic constipation and to assess pediatric patient acceptance of PEG therapy. DESIGN: Prospective observational study. SETTING: Pediatric clinics at a referral center.Patients Eighty-three children (44 with chronic constipation, 39 with constipation and encopresis) receiving PEG therapy for more than 3 months. MAIN OUTCOME MEASURES: Clinical adverse effects related to PEG therapy and acceptance and compliance with PEG therapy. Serum electrolyte levels, osmolality, albumin levels, and liver and renal function test results were measured. RESULTS: At the time of evaluation, the mean duration of PEG therapy was 8.7 months, and the mean PEG dose was 0.75 g/kg daily. There were no major clinical adverse effects. All blood test results were normal, except for transient minimal alanine aminotransferase elevation unrelated to therapy in 9 patients. All children preferred PEG to previously used laxatives, and daily compliance was measured as good in 90% of children. CONCLUSIONS: Long-term PEG therapy is safe and is well accepted by children with chronic constipation with and without encopresis.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12860787&dopt=Abstract

Ned Tijdschr Geneeskd. 2003 Jun 28;147(26):1267-71.
[In Process Citation]

[Article in Dutch]

van Ginkel R, Buller HA, Heymans HS, Taminiau JA, Boeckxstaens GE, Benninga MA.

Afd. Kindergastro-enterologie en voeding, Academisch Medisch Centrum/Emma Kinderziekenhuis, Meibergdreef 9, 1105 AZ Amsterdam.

A detailed medical history in combination with a thorough physical examination, including rectal examination, form the cornerstone in the diagnostic work-up for children with functional defecation disorders. Additional investigations are often not informative and have only minor diagnostic or therapeutic implications. Medical therapy in children with functional constipation and solitary encopresis is primarily based on clinical experience. In both patient groups, the role of education, the use of diary cards and toilet training is important. In some patients behaviour interventions are important. Oral laxatives are the basis of treatment of children with functional constipation, whereas they are contra-indicated in children with solitary encopresis. In both groups, biofeedback training appears to be of little additional benefit. Long-term follow-up of children with functional defecation disorders shows that complaints continue far beyond puberty in many children.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12861667&dopt=Abstract [PubMed - in process]

J Clin Gastroenterol. 2003 Aug;37(2):147-50.
Whole body irrigation for contraband bodypackers.

Farmer JW, Chan SB.

Emergency Medicine Residency Program, Resurrection Medical Center, Chicago, Illinois, USA.

GOALS: Investigate outcomes of contraband body packers treated with whole bowel irrigation (WBI) using oral polyethylene glycol (PEG). Compare with prior studies of treatments using mild laxatives and/or observation. BACKGROUND: Drug smuggling via the gastrointestinal tract has risks including sudden death. Other studies have reported complication rates between 4% and 22%. STUDY: Retrospective case series of patients body packing contraband, and treated with WBI using PEG solution. Outcome measures include length of hospital stay (LOS) and complications. Statistical inferences using Spearman rank correlation and Fisher Exact tests. RESULTS: Sixteen patients with mean age 27.9 (SD 8.8). There were 2 complications (12.5%) and no deaths. There was no significant difference in complication frequency when compared with other reported treatment methods (P = 0.57, P = 0.48, P = 1.0). Mean LOS was 49.4 hours (SD 29.6). There was no correlation between mean LOS and either PEG dose (P = 0.89), drug type (P = 0.76), packet quantity (P = 0.34), or packet weight (P = 0.99). CONCLUSIONS: In this limited case series, WBI with PEG was used to treat contraband body packers with no higher complication frequency than other reported methods. The drug type, packet quantity, packet weight, and PEG dose did not correlate with the length of hospital stay.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12869886&dopt=Abstract [PubMed - in process]

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