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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs

J Nutr Sci Vitaminol (Tokyo). 1998 Dec;44(6):787-98.
Transitory laxative threshold of trehalose and lactulose in healthy women.

Oku T, Okazaki M.

Department of Nutrition, Faculty of Medicine, University of Tokyo, Japan.

The transitory laxative threshold of a partially digestible disaccharide, trehalose, and an undigestible disaccharide, lactulose, was estimated by the dose-response relation between the test substance and the prevalence of diarrhea in 20 healthy female subjects. The subjects ingested several indicated amounts of trehalose or lactulose once daily 2 to 3 h after a meal. The intake of the test substance was stopped at the dose level that caused diarrhea or when the dose reached the maximal level. A record of physical conditions, gastrointestinal symptoms, and fecal conditions was made by all subjects before and after each ingestion of the test substance. Half the subjects experienced no diarrhea even with the ingestion of the maximal dose level (60 g) of trehalose in this study, and the ingestion of up to 40 g of lactulose caused diarrhea in 75% of all subjects. Abdominal symptoms such as flatus, distension, and borborygmus appeared at high prevalence with lactulose and trehalose ingestion, and the effect of lactulose was significantly stronger than that of trehalose at the same dose level (p < 0.05). The quantity of trehalose and lactulose that induced diarrhea differed greatly from person to person. The transitory laxative threshold was estimated as 0.65 g/kg body weight for trehalose and 0.26 g/kg body weight for lactulose by using the regression equation between the dose levels of the test substances and the cumulative incidence of diarrhea. These results suggest that it would be quite acceptable to administer trehalose up to 33 g and lactulose up to 13 g in a person weighing 50 kg.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10197310&dopt=Abstract

J Pediatr Surg. 2002 Oct;37(10):1464-6.
Anterior resection for megarectosigmoid in congenital anorectal malformations.

Hallows MR, Lander AD, Corkery JJ.

Department of Paediatric Surgery, The Birmingham Children's Hospital NHS Trust, and The University of Birmingham, Birmingham, England.

PURPOSE: The aim of this study was to review the effectiveness of resecting dilated distal bowel in children suffering unmanageable constipation or soiling who have been operated on previously for anorectal malformations. METHODS: A retrospective review was performed of 9 children. Each child underwent excision of dilated bowel to leave normal caliber bowel anastomosed by hand to a rectal reservoir at the peritoneal reflection. The documented follow-up was reviewed. RESULTS: The 9 children had primary surgery for the following anomalies: high (n = 1), intermediate (n = 1), low (n = 3), rectal stenosis (n = 3), and anal stenosis (n = 3), Seven children had persistent fecalomas, and 7 had major problems with soiling. All were on large doses of laxatives, with 5 having regular rectal washouts and 4 having regular enemas. In all radiologic studies there was a prompt change from normal caliber bowel to dilated bowel at the upper limit of the dilatation. The mean age at operation for excision was 4 years, 11 months (range, 11 months to 9 years, 11 months). The mean period of follow-up was 4 years, 7 months (range, 2 years, 3 months to 10 years). Follow-up showed that all children improved. None had major complications. All were having between one and 3 bowel actions per day. Three continued to soil but improved. Of the remaining 6, only 2 required occasional laxatives and had regular spontaneous bowel actions without soiling. No child was having enemas or washouts. CONCLUSION: Anterior resection for the treatment of megarectosigmoid is a safe and effective procedure. 2002, Elsevier Science (USA). All rights reserved.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12378455&dopt=Abstract [PubMed - in process]

Hosp Pharm. 1995 Apr;30(4):292-4.
Pharmaceutical care provides positive outcomes for postpartum patients.

Ptashnick MB.

St. Paul's Hospital Pharmacy, Vancouver, British Columbia, Canada.

This study examined a method for incorporating the philosophy of pharmaceutical care into the care of postpartum women to promote patient independence and satisfaction with hospital care. Patients became active participants in their own care through a bedside medication, self-administration program. Results of a patient survey indicated that 146 of 167 patients responded positively to the benefits of the bedside medication program. A self administered medication program for postpartum women allowed for patient controlled analgesic and laxative use. The availability of medications before symptom onset, and the provision of pertinent information on use of medications, allowed patients the independence to make appropriate decisions for their own care.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10141870&dopt=Abstract

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