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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs || hair research abs || hair related research references || testosterone related research references || melanin related research references || nicotine related research references

Cyberpsychol Behav. 2003 Jun;6(3):275-80.
Experimental application of virtual reality for nicotine craving through cue exposure.

Lee JH, Ku J, Kim K, Kim B, Kim IY, Yang BH, Kim SH, Wiederhold BK, Wiederhold MD, Park DW, Lim Y, Kim SI.

Department of Biomedical Engineering, Hanyang University, Seoul, Korea.

Research has shown that many smokers experience an increase in the desire to smoke when exposed to smoking-related cues. Cue exposure treatment (CET) refers to the manualized, repeated exposure to smoking-related cues, aimed at the reducing cue reactivity by extinction. In this study, we constructed a virtual reality system for evoking a desire of nicotine, which was based on the results of a Questionnaire of Nicotine-craving. And we investigated the effectiveness of the virtual reality system as compared to classical device (pictures). As a result, we reached the conclusion that virtual reality elicits more craving symptoms than the classical devices.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12855083&dopt=Abstract [PubMed - in process]

Med Clin (Barc). 2003 Jun 21;121(3):89-4.
[Correlation between carbon-monoxide levels in exhaled air and nicotine-dependence measurements systems (DSM-IV, Fagerstrom test and ARU-SMQ-9) in adolescent smokers]

[Article in Spanish]

Clemente Jimenez ML, Perez-Trullen A, Rubio Aranda E, Marron Tundidor R, Herrero Labarga I.

Especialista en Medicina Familiar y Comunitaria. Unidad Docente de Huestca. CS Perpetuo Socorro. Huesca. Espana.

BACKGROUND AND OBJECTIVE: If we are capable of 1) determining the correlation, in young smokers, between carbon-monoxide levels in exhaled air (CO) and carboxihemoblobine (COHb) (cooximetrically determined) and 2) adapting the versions of the nosologic criteria DSM-IV for nicotine-depencence (DSM-IVa), Fagerstrom Test (FTNDa), and ARU-SMQ-9a Test to adolescents, then we may be able to establish how useful such tests are to measure nicotine-ependences in adolescents. SUBJECTS AND MEHTOD: Cross-sectional, observation-based study carried out in 41 schools. 2,647 students aged 10 to 17 years were surveyed. The size of the sample was calculated for eacha nd using the equation of finite population. For each age, the sample was stratified according to sex and type of school. Schools and students were chosen by using the table of random numbers. Teenagers filled up a questionnaire which included DSM-IVa, FTNDa, and ARU-SMQ-9a and were subsequently given a cooximery. RESULTS: 23.1% were smokers. The correlation between the levels of CO and the nicotine-dependence tests was: DSM-IVa rho o = 0.3390 (p = 0.0000); FTNDa rho o = 0.5853 (p 0 0.000); ARU-SMQ-9a rho o = 0.4670 (p = 0.000). The correlation with the levels of carboxihemoglobine was: DSM-IVa rho o = 0.3369 (p = 0.000); FTNDa *o = 0.5498 (p = 0-000); ARU-SMQ-9a rho o = 0.4460 (p 0 0-000). The study was based on 583 smoking scholars who underwent the cooximetry. CONCLUSIONS: The correlation between DSM-IVa, FTNDa, and ARU-SMQ-9a and the levels of CO and COHb in young smokers is low but meaninful. In our opinion, research to find new, simple, cheap, and easily-accessible tools allowing the correct diagnosis and follow-up of young smokers must continue.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12855132&dopt=Abstract

Brain Res Dev Brain Res. 2003 Jul 12;143(2):233-44.
Transient muscarinic calcium mobilisation in transdifferentiating as in reaggregating embryonic chick retinae.

Naruoka H, Kojima R, Ohmasa M, Layer PG, Saito T.

University of Tsukuba, Institute of Biological Sciences, Tsukuba, Ibaraki 305-8572, Japan.

Two independent in vitro regeneration systems of the embryonic chick retina (E4-5) were used to study the mobilisation of intracellular calcium by the neurotransmitters acetylcholine (ACh) and glutamate, as measured by Fura-2 fluorescence changes. Retinal pigment epithelium (RPE) explants under the influence of basic fibroblast growth factor transdifferentiate into a retina-like tissue with normal laminar organisation, while rosetted spheres reaggregated from fully dispersed cells of the embryonic retina will achieve only an inferior tissue organisation, characterised by regions of an inverted retina [Layer et al., Neuroreport 12 (2001) A39-46]. ACh induced a pronounced Ca(2+) response in young explants, and a similar but less pronounced response in reaggregates; this response decreased almost entirely after 1 week in culture. In contrast, a Ca(2+) response to glutamate became detectable later, continuously increasing during this period. The response to ACh was strictly mediated by muscarinic ACh receptors (mAChRs), since it was inhibited by preincubation with atropine, but not tubocurarine; correspondingly, it was mimicked by muscarine, but not nicotine. Studies with mAChR blockers, preferentially acting on the m1-, m2-, or m3-receptor subtypes, suggested that the muscarine-induced Ca(2+) response is mediated by m1- and/or m3-type mAChRs, but not by the m2-type. These results show that (i) similar to the in vivo retina, in both a transdifferentiating and a reaggregating system an early muscarinic Ca(2+) response is active, which (ii) roughly parallels periods of cell proliferation, and (iii)-as evidenced by the reaggregates-does not depend on any tissue pre-organisation. In contrast, a response to glutamate becomes prominent only when tissue differentiation commences. This is the first demonstration of a physiological response in regenerating chick retinas, supporting their validity as models both of retinal development and regeneration.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12855195&dopt=Abstract [PubMed - in process]

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