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Nippon Shokakibyo Gakkai Zasshi. 2002 Aug;99(8):925-34.
[CT evaluation of infectious colitis]

[Article in Japanese]

Horiki N, Maruyama M, Fujita Y, Suzuki Y, Tanaka T, Imoto I, Adachi Y.

Division of Gastroenterology, St. Luke's International Hospital.

Computed tomography (CT) is useful for evaluating the diagnosis of gastrointestinal disease, such as infectious colitis, in patients with severe pain and bloody diarrhea. During the 7 years between November 1993 and October 2000, 34 patients with infectious colitis (18 male, 16 female; mean age 42 +/- 19 yrs), received emergency CT and colonoscopy because of severe abdominal pain and dysentery. The following organisms were isolated: pathogenic Escherichia coli (12), 6 of which were O157:H7 (O-157), Salmonella species (11), Campylobacter species (5), Vibrio parahaemolyticus (3), Yersinia enterocolotica (2) and Shigella species (1). Thickening of the intestinal wall greater than 10 mm was seen in the ascending colon in the 6 cases with E. coli O 157, in 5/11 cases with Salmonella, 4/5 with Campylobacter and 1/6 with non-O157 pathogenic E. Coli. Marked intestinal wall thickening, greater than 20 mm, was seen in the ascending colon of the 4 of the patients with an O-157 infection. In all patients with O-157 colitis, slight ascites was noted in the pelvic space. In additions, ascites was also seen in 3/13 patients with Salmonella and 1/5 patients with Campylobacter colitis. The CT findings, in the patients with infectious colitis, are non-specific but knowledge and recognition of the findings will help in patient evaluation and proper treatment.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12229165&dopt=Abstract

Invest Clin. 2002 Sep;43(3):145-55.
[Oropharyngeal bacteria in asthmatic patients in the city of Maracaibo, Venezuela]

[Article in Spanish]

Arocha-Sandoval F, Parra-Quevedo K.

Catedra de Bacteriologia y Virologia, Escuela de Medicina, Universidad del Zulia. aroquinvutopia.com

Bronchial asthma is an intercurrent disease that affects a major portion of the population. Neither its etiopathogenesis nor its complications have been fully established. The purpose of this study was to determine the composition of oropharyngeal bacterial flora in asthmatic patients and compare it with oropharyngeal bacterial flora in a group of healthy patients in order to establish its relationship with the pathogenesis of asthma and its complications. A sample consisting of 116 pharyngeal swabs was analysed from march 1995 to december 1996. 58 of the total amount of pharyngeal swabs corresponded to asthmatic patients (during asthmatic crisis), while the other 58 corresponded to healthy subjects. Common bacteriological culture techniques were carried out in order to obtain the bacteriological diagnosis. The results showed that isolation of transitory flora bacteria in asthmatic patients was 75.8%, which was significantly higher (p < 0.05) than in the control group (27.5%). Streptococcus pyogenes was the most frequent isolated bacteria in the group of asthmatic patients (17.2%), while Escherichia coli was the most frequent bacteria in the control group. No significant difference was found regarding sex and the presence of transitory flora bacteria. It was also found that enterobacteria and non fermenting negative gram bacillus increased with age in both groups; a higher incidence was observed in the group of 40-year-old subjects. These finding confirm the existence of a relationship between the asthmatic condition and the percentage of transitory bacterial flora carriers. The explanation to this phenomenon might be the frequent use of antibiotics and the possible contamination of the micro-nebulization equipment used for the treating the asthma crisis. This data must be considered when applying empiric therapy in asthmatic patients complicated with pneumonia. The possibility that certain infectious agents, including bacteria, could play a role in asthma pathogenesis is one of the questions that should be answered in future studies on this topic.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12229277&dopt=Abstract

Environ Monit Assess. 2002 Sep;78(2):101-10.
E. coli kinetics--effect of temperature on the maintenance and respectively the decay phase.

Darakas E.

Department of Civil Engineering, Aristotle University of Thessaloniki, Greece. darakaivil.auth.gr

The knowledge of enteric bacteria survival kinetic is very important for environmental scientists. Enteric bacteria and specifically the fecal indicator bacteria are typically used to measure the sanitary quality of water for recreational, industrial, agricultural and water supply purposes. They are released into the environment with feces, and are then exposed to a variety of environmental conditions that eventually cause their death. In general, it is believed that the fecal indicator cannot grow in natural environments, since they are adapted to live in the gastrointestinal tract. Studies have shown that fecal indicator bacteria survive from a few hours up to several days in surface water, but may survive for days or months in lake-sediments, where they may be protected from sunlight and predators. We assume that pathogens similar to the fecal indicator bacteria die at the same rate as fecal indicator bacteria. Therefore, if we find relatively high numbers of fecal indicator bacteria in an environment, we assume that there is an increased likelihood of pathogens being present as well. The kinetic of enteric bacteria survival in natural waters is affected by a large number of factors. One of them is the temperature. The aim of this contribution was the experimental research of the survival kinetic of enteric bacteria applying a simple mathematical formula, which describes the survival kinetic predicting the decay phase at various temperatures. We aspire that the results will lead both to the solution of many engineering problems and to future research.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12229917&dopt=Abstract

Biol Pharm Bull. 2002 Sep;25(9):1161-4.
Effect of chitosan oligosaccharide on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in mice.

Shon YH, Park IK, Moon IS, Chang HW, Park IK, Nam KS.

Department of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University, Kyongju, Korea.

The abilities of two types of chitosan oligosaccharides, chitosan oligosaccharide I (1-kDa<MW<3-kDa) and chitosan oligosaccharide II (3-kDa<MW<5-kDa), to prevent 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative stress were examined in ICR mice. Chitosan oligosaccharide I had no effect on TCDD-induced alterations in lipid peroxidation and glutathione S-transferase activity or liver weight change. However, mice treated with chitosan oligosaccharide II were protected from TCDD-induced lipid peroxidation, inhibition of glutathione peroxidase and glutathione S-transferase activities, and losses in body and liver weights. These results suggest that chitosan oligosaccharide might be a potential agent for combating TCDD-induced pathogenesis.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12230109&dopt=Abstract

Clin Otolaryngol. 2002 Dec;27(6):472-9.
Paroxysmal hemicrania and cluster headache: two discrete entities or is there an overlap?

Fuad F, Jones NS.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Nottingham, Nottingham, UK.

Paroxysmal hemicrania has been described as an excruciating unilateral pain, which is usually ocular and frontotemporal with short-lasting (2-45 min), frequent attacks (usually more than five per day); with marked autonomic features (rhinorrhoea, nasal congestion, conjunctival injection, lacrimation) and unilateral to the pain. A response to indomethacin is essential using the current criteria for the diagnosis. It is a rare condition but when it occurs it is misdiagnosed as being due to sinusitis. A retrospective analysis of 11 patients seen in the period 1995-2001 suggests that there is an overlap between paroxysmal hemicrania and cluster headache. Four patients had all the characteristics of paroxysmal hemicrania and responded to indomethacin. Four other patients fulfilled the criteria except for the frequency and length of the attacks. They only had one attack per day and these lasted more than 2 h. Another patient had all the symptoms of paroxysmal hemicrania and did not respond to indomethacin, but responded to triptans and pizotifen. Patients with cluster headache typically respond to these. Two patients were unable to continue taking indomethacin owing to severe gastrointestinal upset. In the same period, we also had 30 patients with cluster headaches. There is increasing evidence that paroxysmal hemicrania and cluster headache share a similar pathogenesis and that they may not always be so discrete in either their response to indomethacin or their periodicity.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12472514&dopt=Abstract

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