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Eur J Neurol. 2000 Sep;7(5):499-508.
Patterns of cerebrovascular symptomatology associated with carotid atheroma.

Tegos TJ, Sabetai MM, Nicolaides AN, Elatrozy TS, Dhanjil S, Thomas DJ.

Irvine Laboratory for Cardiovascular Investigation and Research, Department of Vascular Surgery, St. Mary's Hospital, Imperial College of Science, Technology and Medicine, Praed St, Paddington, London, UK. t.tegoc.ac.uk

The aim of this study was to identify ultrasonic tissue characteristics and stenosis of carotid plaques that correspond to amaurosis fugax, hemispheric transient ischaemic attack, and stroke. At total of 146 symptomatic carotid plaques (136 patients) associated with amaurosis fugax, hemispheric transient ischaemic attack, stroke, and having 50-99% stenosis on duplex, were studied. These plaques were imaged on duplex, captured in a computer and their grey scale median was evaluated to distinguish the dark (low grey scale median) from the bright (high grey scale median) plaques. Stenosis was assessed on duplex. The amaurosis fugax group corresponded to carotid plaques with low grey scale median and severe stenosis, as contrasted with the other two groups (hemispheric transient ischaemic attack and stroke) (P < 0.05). These results suggested that amaurosis fugax was dependent only on the instability of carotid plaques, whereas hemispheric transient ischaemic attack and stroke were both dependent on carotid plaques and other pathogenetic factors.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11054134&dopt=Abstract



Eur J Neurol. 2000 Sep;7(5):541-7.
Elevation of serum soluble E-selectin and antisulfoglucuronyl paragloboside antibodies in amyotrophic lateral sclerosis.

Ikeda J, Kohriyama T, Nakamura S.

Third Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3, Kasumi, Minami-ku, 734-8551 Hiroshima, Japan. june925ol.com

Immunological abnormality is often found in amyotrophic lateral sclerosis (ALS). Antibodies to sulfoglucuronyl paragloboside (SGPG) were reported in ALS, although the pathogenetic significance of the antibodies is still unknown. We have already demonstrated that SGPG, a unique glycolipid, is present in both peripheral nerve and vascular endothelial cells. To investigate whether serum anti-SGPG antibodies would participate in activation and/or injury of endothelial cells in ALS, we examined serum anti-SGPG antibodies in association with serum soluble E- and P-selectins, which are markers of activated endothelial cells, in 25 patients with ALS and 14 age-matched patients with other neurological diseases (ONDs) using the microtiter-ELISA method. Seven out of 25 ALS patients had anti-SGPG antibodies. Levels of sE-selectin were significantly higher in patients with ALS (48.5 +/- 23.4 ng/ml) compared with ONDs (24.0 +/- 11.8 ng/ml) (P < 0.005). Four out of seven ALS patients with anti-SGPG antibodies had concomitantly high sE-selectin levels. The mean sE-selectin levels were higher in patients with anti-SGPG antibodies (61.9 +/- 25.2 ng/ml) than in those without anti-SGPG antibodies (43.3 +/- 21.1 ng/ml). Anti-SGPG antibodies may take part in the activation and/or injury of endothelial cells. The increased expression of E-selectin may be related to an immunological process in some ALS patients.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11054140&dopt=Abstract



Eur J Neurol. 2000 Sep;7(5):577-9.
Lesion of the anterior branch of axillary nerve in a patient with hereditary neuropathy with liability to pressure palsies.

Simonetti S.

Division of Neurology, E. O. Ospedali Galliera, Genoa, Italy. simonettalliera.it

We report the case of a 30-year-old woman affected by hereditary neuropathy with liability to pressure palsies (HNPP), who developed a painless left axillary neuropathy after sleeping on her left side, on a firm orthopaedic mattress, in her eighth month of pregnancy. Electromyography (EMG) showing neurogenic signs in the left anterior and middle deltoid, and normal findings in the left teres minor, posterior deltoid and other proximal upper limb muscles, demonstrated that the lesion was at the level of the axillary anterior branch. A direct compression of this branch against the surgical neck of the humerus seems the most likely pathogenic mechanism. This is the first documented description of an axillary neuropathy in HNPP. Knowledge of its possible occurrence may be important for prevention purposes.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11054147&dopt=Abstract



J Appl Microbiol. 2000 Oct;89(4):587-94.
A membrane-immunofluorescent-viability staining technique for the detection of Salmonella spp. from fresh and processed meat samples.

Duffy G, Kilbride B, Sheridan JJ, Blair IS, McDowell DA.

The National Food Centre, Teagasc, Dublin 15, Ireland. g.dufffc.teagasc.ie

A direct staining technique was investigated for the detection of viable Salmonella in fresh and processed meats. The technique involved overnight enrichment in BPW, extraction of Salmonella cells onto a polycarbonate membrane, followed by detection of the pathogen using anti-Salmonella monoclonal antibody coupled with an antibody linked-fluorescent stain (Texas Red) and a viability stain (Sytox Green). The technique was applied to the detection of Salm. enteritidis inoculated into broth culture or minced beef and then subjected to a variety of stresses including freezing (- 20 degrees C), heating (2 or 4 min at 56.9 degrees C), low pH (5 or 3.5) or high salt (2 or 4%). The correlation between traditional plate counts and the rapid count varied widely (r2 = 0.98-0.03), depending on the type and level of stress applied to the cells. The reason for the disparity in results obtained, and the potential application of the method as a diagnostic tool, are discussed.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11054161&dopt=Abstract



J Appl Microbiol. 2000 Oct;89(4):595-8.
Direct microscopy of bacillus endospore germination in soil microcosms.

Thrane C, Olsson S, Wolstrup J, Sorensen J.

Section of Genetics and Microbiology, Department of Ecology, The Royal Veterinary and Agricultural University, Copenhagen, Denmark. ctvl.dk

Antagonistic endospore-forming Bacillus spp. offer a large potential as seed inoculants for control of soil-borne pathogens. In the soil, however, inoculated Bacillus endospores may remain dormant without germination, and plant protection can therefore be inefficient and unpredictable. A method based on direct fluorescence microscopy in soil microcosms was used to determine whether low-cost organic additives incorporated into seed coating material could stimulate endospore germination. Complex organic additives supported a high level of endospore germination of the fungal antagonist Paenibacillus polymyxa CM5-5. Skim milk is a low-cost additive that may be incorporated into seed coating material for efficient induction of Bacillus endospore germination in soil.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11054162&dopt=Abstract








Natural Herbal Supplement: Hair Million


Hair loss alone does not pose significant health problems. In fact, there are people who opt for baldness as an alternative hair style. However, in general, however, hair loss is not considered desirable.

The most ostensive feature that distinguishes us human from chimps and other primates is the lack of bodily hair. During evolutionary process, we have lost the majority of hair. Hair is no longer a biologically essential part of our body, just like appendix. The hair we still have on our scalp and a few other bodily parts is still regarded as significant for reasons other than biological necessity. Hair loss is naturally accompanied by aging process, although the extent of hair loss and the timing of onset vary widely among individuals. Thus, loss of hair and baldness is considered as a symbol of maturity or old age. Like winkles and other signs of aging, hair loss is not welcome by most people, because we don't welcome aging, and being perceived as an aging person. However, it is alopecia, or premature hair loss that especially concerns certain people.

While the hair loss and resulting baldness in general have not been proven to be related to underlying health problems, there are certain correlations between hair loss and health problems. For instance, premature hair loss could suggest premature aging or nutritional and hormonal imbalance, stressful life, use of drugs that cause hair loss as a side effect, skin disease, or heart disease. The balding appearance could also impart a subdued impression of integrity in bodily health and youthfulness.














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