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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs

J Bacteriol. 2003 Apr;185(7):2362-8.
Genome organization and molecular analysis of the temperate bacteriophage MM1 of Streptococcus pneumoniae.

Obregon V, Garcia JL, Garcia E, Lopez R, Garcia P.

Departamento de Microbiologia Molecular, Centro de Investigaciones Biologicas, CSIC, 28006 Madrid, Spain.

The genome of MM1 (40,248 bp), a temperate bacteriophage from the Spain(23F)-1 multiresistant epidemic clone of Streptococcus pneumoniae, is organized in 53 open reading frames (ORFs) and in at least five functional clusters. Bioinformatic and N-terminal amino acid sequence analyses enabled the assignment of possible functions to 26 ORFs. Analyses comparing the MM1 genome with those of other bacteriophages revealed similarities, mainly with genomes of phages infecting gram-positive bacteria, which suggest recent exchange of genes between species colonizing the same habitat.

PMID:_12644508 Curr Infect Dis Rep. 1999 Apr;1(1):13-21.
Streptococcus pneumoniae: Activity of Newer Agents Against Penicillin-Resistant Strains.

Jacobs MR, Appelbaum PC.

Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA.

Strains of pneumococci resistant to antimicrobial agents have been reported on all continents. In 1997, more than 50% of strains in the United States were not susceptible to penicillin, and 30% were resistant to macrolides. In addition, many strains are resistant to multiple agents, including beta-lactams, macrolides, clindamycin, chloramphenicol, tetracyclines, and trimethoprim-sulfamethoxazole. Although resistance to beta-lactams in nonmeningeal infections can usually be overcome by parenteral administration, clinically significant resistance is an important limitation in meningitis and with oral administration of beta-lactams. Decisions about treatment of pneumococcal infection are based on the site of infection, the degree of resistance to penicillin G, the presence of resistance to other agents, the severity of disease, the presence of underlying conditions, and the dose and route of administration of antimicrobial agents. The application of pharmacokinetic and pharmacodynamic variables to pneumococci has greatly improved the interpretation of susceptibility data and the development of clinically relevant breakpoints.

PMID:_11095761 [PubMed - as supplied by publisher] Curr Infect Dis Rep. 1999 Apr;1(1):49-56.
Community-Acquired Pneumonia: An Overview.

Kanno MB, Brown PD.

Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine/Detroit Medical Center; and Harper Hospital, 4 Yellow Center, 3990 John R., Detroit, MI 48201, USA.

Community-acquired pneumonia (CAP) accounts for a significant number of hospitalizations and outpatient visits, as well as substantial health care expenditures. CAP is particularly common among the elderly who account for more than 90% of deaths due to pneumonia. Streptococcus pneumoniae is believed to be the most common microbial etiology of CAP, but recent studies suggest that the atypical pathogens may be more common than previously thought, particularly among ambulatory patients. Recent studies have provided data regarding risk of mortality and process of care and outcomes. Increasing resistance among strains of S. pneumoniae has impacted the approach to the empiric therapy of CAP. The Infectious Diseases Society of America published guidelines for the evaluation and management of CAP this past year. Pathogen-specific therapy guided by the results of sputum gram stain and culture is emphasized. Despite enthusiasm for practice guidelines and clinical pathways, there remains insufficient published data to determine their impact on quality and cost of care in patients with CAP.

PMID:_11095767 [PubMed - as supplied by publisher] Curr Infect Dis Rep. 1999 Apr;1(1):57-64.
Pneumococcal Pneumonia.

Mufson MA.

Department of Medicine, Marshall University School of Medicine, 1600 Medical Center Drive, Suite G500, Huntington, WV 25701-3655, USA.

Pneumococcal pneumonia accounts for about one-sixth to two-thirds of all cases of community-acquired pneumonia. Its high frequency of occurrence worldwide and the high number of deaths associated with it--especially with bacteremic (invasive) disease--mark its importance. Invasive disease is associated with case-fatality rates of 15% to 25% among elderly adults. Penicillin-resistant Streptococcus pneumoniae (PRSP) first appeared in the 1970s, and its increased incidence in the late 1980s signaled its emerging importance. In individual patients in whom PRSP infection is suspected, the clinician must follow guidelines for empiric antibiotic therapy for community-acquired pneumonia until microbiological test results are known. When a diagnosis of pneumococcal pneumonia is established, the clinician should change to a regimen that targets the pneumococcus. Adults at highest risk for death from pneumococcal pneumonia include immunocompetent persons with underlying chronic diseases, immunocompromised persons, elderly persons, and unvaccinated residents of nursing homes and other chronic care facilities. Safe and effective, polyvalent polysaccharide pneumococcal vaccine should be used in persons 2 years of age and older who are at increased risk for serious pneumococcal pneumonia and in all persons 65 years of age and older.

PMID:_11095768 [PubMed - as supplied by publisher] Curr Infect Dis Rep. 1999 Apr;1(1):65-72.
Legionella.

File TM, Plouffe JF.

Infectious Disease Service, Summa Health System, 75 Arch Street, Suite 105, Akron, OH 44304, and Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA.

Since the identification of Legionella two decades ago, a vast amount of information has accumulated concerning the microbiology, clinical manifestations, and therapy of infections due to these organisms. There are now more than 40 species of Legionella identified. The spectrum of legionellosis ranges from asymptomatic infection to serious pneumonia. Two clinical syndromes have been identified: Legionnaire's disease and Pontiac fever. Recent information suggests that the newer macrolides and newer fluoroquinolones are preferred therapy for serious disease.

PMID:_11095769 [PubMed - as supplied by publisher]

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