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Schizophrenia research abs
Psychiatr Prax. 2002 Oct;29(7):388-91.
[The risk of rehospitalisation during therapy with atypical and typical neuroleptics--a contribution to differential indication]
[Article in German]
Muller P, Nerenz H, Schaefer E.
Universitatsklinik fur Psychiatrie und Psychotherapie, Gottingen, Germany.
Atypical neuroleptics have a lot of advantages compared with conventional substances. It is still disadvantageous that a depot-medication is missing. The role of the form of application has been studied in a schizophrenia-out-patient department. In 25 out-patients under therapy with atypical neuroleptics the time of rehospitalisation per year was retrospectively determined and compared with that of 25 out-patients receiving depot-medication. Both groups were comparable with regard to some patient-characteristics and predictors of the course of the disease. It turned out that for patients with depot-neuroleptics the time spent in hospital per year was half of that for patients under atypical drugs. It had been in the same range in both groups 4 to 6 years ago and had decreased until the last year of the catamnesis in patients with depot-medication, but not in those with atypics. Typical neuroleptics as oral medication are disadvantageous in this respect. Despite efforts to reach a good compliance in all patients, preferable effects of atypical drugs with regard to negative symptoms are opposed by less favourable rehospitalisation times. This has to be taken into consideration in differential indication.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12378421&dopt=Abstract
Zh Nevrol Psikhiatr Im S S Korsakova. 2002;102(9):14-7.
[Obsessive doubts by contrast]
[Article in Russian]
Volel' BA.
Obsessive doubts by contrast, along with traditional obsessions, refer to a kind of obsessive states, for which contrast content presentations provide a basis for obsession appearance accompanied by irresistible drive for walking off a psychogenic situation. Obsessive doubts by contrast are formed due to a conflict between equally attractive but incompatible wishes. The content of contrast throught is not absurd but reflects a real traumatizing situation. A study of 28 patients revealed they have psychasthenic accentuation as a personal feature in common. Obsessive doubts by contrast may develop both in the terms of affective disorders and schizotypical disorder (slow progredient schizophrenia). They have current character and in a number of cases transform into other obsessive-phobic states.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12378875&dopt=Abstract
Zh Nevrol Psikhiatr Im S S Korsakova. 2002;102(9):4-8.
[Clinical and nosological approach to diagnosis of schizoaffective psychosis]
[Article in Russian]
Panteleeva GP, Bologov PV.
Using clinical and psychopathological method, 134 patients who met the ICD-10 criteria of diagnosis of schizoaffective psychosis (F25), were examined. Relatively small prognostic informative value of standard schizoaffective psychosis differentiation into affective- and schizo-dominant types was found. Subtyping of schizoaffective psychosis according to peculiarities of delusion formation in the picture of the disease attacks proved to be more significant. Given clinico-psychopathological features of circular affective and delusional disorders and their pathokinesis, as well as dynamics types and disease outcome, a schizoaffective psychosis systematization has been elaborated. That includes 3 nosologic types: "nuclear" type with non-progressive phase dynamics; "marginal" (intermediate) type and schizoaffective type of attack-like progressive schizophrenia. The concept of nosologic independence of schizoaffective psychosis ("nuclear" type) is discussed.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12378881&dopt=Abstract
Psychiatry Res. 2002 Sep 15;112(1):13-26.
Perseveration in schizophrenia: failure to generate a plan and relationship with the psychomotor poverty subsyndrome.
Lanser MG, Berger HJ, Ellenbroek BA, Cools AR, Zitman FG.
Department of Psychoneuropharmacology, University Medical Centre St Radboud, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.
Although perseveration in the Wisconsin Card Sorting Test (WCST) has been studied extensively in schizophrenia, the underlying cognitive dysfunctions are not yet clear. In schizophrenia, perseveration has been found to relate to frontal and striatal abnormalities. Therefore, both a failure to generate a plan as seen in patients with frontal abnormalities, or a failure to execute a plan as observed in Parkinson patients, who suffer primarily from striatal abnormalities, could explain perseveration in schizophrenia. The aim of the present study was to distinguish between these two cognitive dysfunctions, which are described by Frith in his routes-to-action model. The main difference between these dysfunctions is the ability to use external guidance. In the present study, 39 schizophrenic patients and 36 healthy controls were assessed with the California Verbal Learning Test (CVLT) and the WCST, in which use of external guidance can be measured, and with the Positive and Negative Syndrome Scale (PANSS) to determine the relationship with symptomatology. The results showed that half of the schizophrenic patients showed perseveration, which could be explained by a failure to generate a plan and was related to the psychomotor poverty subsyndrome. No evidence was found for a failure to execute a plan. Type of antipsychotic medication used (atypical vs. typical) proved not relevant. The results are discussed in the light of evidence for involvement of the dorsolateral prefrontal cortex in perseveration in schizophrenia.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12379447&dopt=Abstract
Hair loss is a problem in modern soceity. Examining the factors of hair growth may
shed light on how hair loss might occur.
How long can hair grow before it stops growing eventually if it does?
Given that the hair growth rate is quite uniform and constant, somewhere between 0.3-0.5 millimeters per day, it's believed that the length of anagen, the growth phase, differs among individuals, and this is the major determinant to the maximum hair length. For some individuals, anagen may last ten years. Of course the length of the anagen is governed by genes, and the genetic background of the individuals. Non-genetic factors such as nutritional condition, weather, seasonal changes (hair may grow a bit faster during winter), taking medications, health condition may of course influence the rate of
hair growth as well as
hair loss.
The shape of the hair, straight or curly, is dependent on the shape of the follicle. A circular or round hair follicle would generate straight hair, while the follicle with oval or elliptical shapes (in its cross-section) would produce a curly hair.
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