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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs

Med Hypotheses. 2000 Jul;55(1):40-2.
The prevalence of asthma appears to be inversely related to the incidence of typhoid and tuberculosis: hypothesis to explain the variation in asthma prevalence around the world.

Jones PD, Gibson PG, Henry RL.

University of Newcastle. pioneail.newcastle.edu.au

The prevalence of asthma varies widely throughout the world. We now believe that asthma is due to airway inflammation caused by an imbalance of the T-lymphocytes in the airway. The atopy that drives asthma is due to a predominance of Th2 lymphocytes in the airway. This paper links the prevalence of asthma inversely to the prevalence of tuberculosis and enteric infection. We will argue that the reason we observe such marked variations in the prevalence of asthma around the world is the fact that in the developing world there is a survival advantage in the fetal immune response to mature from Th2 to Th1 lymphocyte predominant. A Th1 response is required to combat infectious diseases such as typhoid and tuberculosis. Data from the World Health Organization confirms that these two infectious diseases occur very rarely in those communities where the asthma is high. It may be that the clean and infection-free environment of Australia and New Zealand is responsible for the region of Oceania having the dubious honor of having the highest prevalence of asthma in the world.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11021324&dopt=Abstract

Aust Vet J. 2000 Sep;78(9):622-4.
Use of the polymerase chain reaction assay for the detection of Mycobacterium avium subspecies paratuberculosis in blood and liver biopsies from experimentally infected sheep.

Gwozdz JM, Thompson KG, Murray A, West DM, Manktelow BW.

Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand. Jacek.Gwozdre.vic.gov.au

OBJECTIVE: To evaluate a polymerase chain reaction-based assay for the detection of Mycobacterium avium subsp paratuberculosis in blood and liver biopsies from subclinically infected sheep. STUDY DESIGN: A direct PCR assay for the detection of M a paratuberculosis was applied to liver biopsy specimens and to samples of blood that were sequentially collected over 53 weeks from 14 sheep infected experimentally with the organism. RESULTS: Of 117 blood samples from the 14 experimentally infected sheep, two tested positive in the PCR assay. Both positive results were obtained in two subclinically infected sheep that had paratuberculosis later confirmed by histological examination at necropsy. However, the assay failed to detect the target DNA in samples of blood from five other sheep with histologically confirmed paratuberculosis. Similarly, the PCR assay on liver biopsy specimens collected 32 weeks after administration of M a paratuberculosis gave only two positive results, both of which were obtained in sheep with histological evidence of paratuberculosis. CONCLUSIONS: The PCR assay on blood and liver biopsies does not provide a useful method for the diagnosis of M a paratuberculosis infection in subclinically infected sheep.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11022290&dopt=Abstract

J Perinat Med. 2002;30(5):423-5.
Congenital tuberculosis proven by percutaneous liver biopsy: report of a case.

Chou YH.

Division of Neonatology, Chang Gung Children's Hospital, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan. yhchodm.cgmh.org.tw

A female term neonate with congenital tuberculosis presented with clinical manifestations of cough, respiratory distress and bilateral reticulonodular infiltration on chest radiograph. Her Indonesian mother had extrapulmonary tuberculosis. The neonate's tuberculosis symptoms were characterized by multi-organ involvement including lung, liver, gall bladder and kidneys, suggesting a spreading hematogenous transmission. Pathology of the liver biopsy revealed scattered miliary granuloma. After anti-tuberculosis treatment, significant improvement was seen on chest radiogram and in her clinical condition. Congenital tuberculosis should be suspected in infants who are unresponsive to empirical antibiotics. Transcutaneous liver biopsy may help confirm its prenatal origin.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12442608&dopt=Abstract

Rev Assoc Med Bras. 2000 Apr-Jun;46(2):174-6.
[Bronchofibroscopy in the etiologic diagnosis of lung diseases in patients with acquired immunodeficiency syndrome]

[Article in Portuguese]

da Silva RM, Chterpensque A.

Servico de Pneumologia, Universidade Federal de Santa Catarina, Florianopolis.

PURPOSE: To evaluate the role of bronchoscopy in diagnosis of pulmonary disease in acquired immunodeficiency syndrome. METHODS: This study analyses a group of 49 patients with AIDS diagnosis admitted at Nereu Ramos Hospital-Florianopolis-SC. It was selected patients with respiratory symptoms and radiologic signs of pulmonary disease, without etiological diagnosis by sputum analysis. These patients were submitted to bronchoscopy with bronchoalveolar lavage, bronchial brush and transbronchial biopsy. The samples were analyzed by BAAR, cytomegalovirus, P. carinii, other fungus and bacterioscopy by Gram. RESULTS: The bronchoscopy was effective on the realization of etiological diagnosis of 71.43% of the cases. The transbronchial biopsy was the most positive technique which confirmed the diagnosis of 59.18% of the cases. The technique with the least positivity was the bronchial brush, with a diagnosis of 4.08% of the cases. The most frequent etiological agent was P. carinii (42.8%), followed by M. tuberculosis (22.86%). No complication was observed in the procedures making. CONCLUSION: The conclusion of this present study was that the bronchoscopy is a secure procedure, with good diagnosis performance for pulmonary disease in this group of patients.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11022358&dopt=Abstract

Respirology. 2000 Sep;5(3):297-9.
A case of pulmonary tumour embolism mimicking miliary tuberculosis.

Chai L, Ong KC, Ng SB.

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.

Pulmonary metastases from choriocarcinoma can very rarely give rise to a 'miliary' pattern on the chest X-ray. A 23-year-old woman with a diffuse nodular pattern on chest X-ray died due to acute respiratory failure and cor pulmonale. At autopsy, choriocarcinoma of the uterus was found. In the lungs, multiple macrovascular tumour emboli within branches of pulmonary muscular arteries in the region of segmental/subsegmental bronchi were detected. There was no evidence of pulmonary parenchymal metastases, pneumonia or tuberculosis. The 'miliary' pattern of pulmonary metastases described in cases of choriocarcinoma may be due to large vessel intra-arterial tumour emboli rather than disseminated parenchymal metastases.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11022995&dopt=Abstract

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