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Weight loss herbal formula for menopause and pms||Ginkgo biloba||
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Tuberculosis research abs
Ai Zheng. 2002 Sep;21(9):1002-4.
[Significance of detecting serum tumor supplied group of factors in differential diagnosis of neck masses]
[Article in Chinese]
Kuang GQ, Yang RN, Mo LG.
Department of Head and Neck, Cancer Hospital, Guangxi Medical University, Nanning 530021, P. R. China.
BACKGROUND & OBJECTIVE: It was reported that serum tumor supplied group of factors (TSGF) were useful in differential diagnosis of various benign and malignant tumor. However, there was little report involving the differential diagnosis of neck masses. This study was designed to evaluate the significance of serum TSGF in differential diagnosis of neck masses. METHOD: Serum TSGFs on the samples from 128 patients with neck masses were detected by immunohistochemistry. Forty seven non-tumor patients served as control. RESULTS: Serum TSGF level and positive rate in various malignant group (including nasopharyngeal carcinoma, non-Hodgkin's disease, and metastatic carcinoma which primary lesion remained unknown) were higher than that in benign mass group (including cervical lymphoadenitis, or reactive hyperplasia, and neck lymphoid tuberculosis without general active tuberculosis), with very significant difference (all P < 0.01). There was no significant difference between two benign masses or neck benjgn masses or neck benign masses and non tumor patients (all P > 0.05). The differential diagnosis parameters of positive serum TSGF for neck malignant masses were: sensitivity 78.16%, specificity 75.61%, efficiency 77.34%, positive predictive value [PV(+)] 87.18%, negative predictive value [PV(-)] 62.00%. CONCLUSION: Determination of serum TSGF was useful in differential diagnosis of neck masses.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12508551&dopt=Abstract
Indian J Med Sci. 2002 Feb;56(2):73-8.
Treatment of tuberculosis: is our knowledge adequate?
Bhalla A.
Department of Medicine, Government Medical College and Hospital, Sector 32, Chandigarh.
Tuberculosis remains a global problem even after the excellent drugs available to cure it. Inappropriate and inadequate treatment leads to acquired drug resistance, which may result in treatment failure and spread of resistant organisms to other persons. Our study was aimed at finding out the current status of knowledge, attitude and practice of resident doctors and consultants medical institutes in two different parts of India. All the residents and consultants were given a questioner containing twenty questions based on WHO guidelines for treatment of tuberculosis and the positive responses were calculated. The results were tabulated in the form of percentage of correct responses to individual queries. 80 doctors responded by filling up the questioner. None of the respondents could correctly answer all 20 questions. Only four could answer more than 75% questions correctly and only 17 could answer at least 50% of the questions correctly. 17.5% respondents could not even answer 25% questions correctly. The details of answer to individual queries presents a dismal picture. This study looked at their present knowledge attitude and treatment practice of a very common but serious disease like tuberculosis and the inadequacy of our knowledge in this regards should make us think about reshaping our policies for managing tuberculosis.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12508617&dopt=Abstract
Int J Syst Evol Microbiol. 2002 Nov;52(Pt 6):1991-6.
Mycobacterium holsaticum sp. nov.
Richter E, Niemann S, Gloeckner FO, Pfyffer GE, Rusch-Gerdes S.
Forschungszentrum Borstel, National Reference Centre for Mycobacteria, D-23845 Borstel, Germany. erichtez-borstel.de
Strains of a novel species of the rapidly growing mycobacteria, Mycobacterium holsaticum sp. nov., were isolated from various clinical specimens. The isolates grew at 22-40 degrees C, were positive for nitrate and tellurite reduction, had phosphatase, urease, nicotinamidase and pyrazinamidase activities, were resistant to isoniazid and rifampin and were susceptible to streptomycin and ethambutol. Analyses of the 165 rRNA gene and a fragment of the heat-shock protein gene hsp65 revealed unique nucleotide sequences. A phylogenetic analysis based on the comparison of the 16S rDNA sequence with that of other mycobacterial species allocated the strain to the rapidly growing mycobacteria. A conspicuous characteristic of the novel species is the similarity of the species-specific sequence of the 16S rRNA gene to the sequence of the Mycobacterium tuberculosis complex, resulting in a cross-reaction with the AccuProbe for the M. tuberculosis complex when performed with a 5 min selection step. The type strain of the novel species is strain 1406(T) ( = DSM 44478(T) = CCUG 46266(T)). Another strain of M. holsaticum sp. nov., strain 5050, which differed in the internal transcribed spacer sequence, was deposited as DSM 44479 ( = CCUG 46267).
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12508858&dopt=Abstract
Int J Syst Evol Microbiol. 2002 Nov;52(Pt 6):2135-40.
Mycobacterium lacus sp. nov., a novel slowly growing, non-chromogenic clinical isolate.
Turenne C, Chedore P, Wolfe J, Jamieson F, Broukhanski G, May K, Kabani A.
National Reference Centre for Mycobacteriology, National Microbiology Laboratory, Population and Public Health Branch, Health Canada, Winnipeg, Manitoba, Canada R3E 3R2. cturennc-sc.gc.ca
A strain of a novel non-chromogenic mycobacterium was isolated from synovial tissue from a 68-year-old female with bursitis of her right elbow. The slowly growing strain had a unique PCR-restriction enzyme analysis (PRA) profile of the hsp65 gene and 16S rRNA gene sequence in comparison with other mycobacterium species. The most closely related species, as determined by 16S rRNA gene sequence analysis, are Mycobacterium malmoense, Mycobacterium marinum, Mycobacterium ulcerans and members of the Mycobacterium tuberculosis complex. The HPLC and biochemical profiles resembled those of Mycobacterium gastri, although differences were noted in the peak-height ratio of the HPLC pattern and the nitrate and pyrazinamidase tests. On the basis of PRA, HPLC, biochemical and 16S rRNA gene sequence analyses, the name Mycobacterium lacus sp. nov. is proposed for this potential pathogen. The type strain is strain NRCM 00-255(T) (= ATCC BAA-323(T) = DSM 44577(T)).
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12508880&dopt=Abstract
Mol Cell Biol. 2003 Jan;23(2):526-33.
Regulation of tumor necrosis factor alpha gene expression by mycobacteria involves the assembly of a unique enhanceosome dependent on the coactivator proteins CBP/p300.
Barthel R, Tsytsykova AV, Barczak AK, Tsai EY, Dascher CC, Brenner MB, Goldfeld AE.
The Center for Blood Research. Department of Medicine, Harvard Medical School. The Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Tumor necrosis factor alpha (TNF-alpha) plays an important role in host containment of infection by Mycobacterium tuberculosis, one of the leading causes of death by an infectious agent globally. Using the pathogenic M. tuberculosis strain H37Rv, we present evidence that upon stimulation of monocytic cells by M. tuberculosis a unique TNF-alpha enhanceosome is formed, and it is distinct from the TNF-alpha enhanceosome that forms in T cells stimulated by antigen engagement or virus infection. A distinct set of activators including ATF-2, c-jun, Ets, Sp1, Egr-1 and the coactivator proteins CBP/p300 are recruited to the TNF-alpha promoter after stimulation with M. tuberculosis. Furthermore, the formation of this enhanceosome is dependent on inducer-specific helical phasing relationships between transcription factor binding sites. We also show that the transcriptional activity of CBP/p300 is potentiated by mycobacterial stimulation of monocytes. The identification of TNF-alpha regulatory elements and coactivators involved in M. tuberculosis-stimulated gene expression thus provides potential selective molecular targets in the modulation of TNF-alpha gene expression in the setting of mycobacterial infection.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12509451&dopt=Abstract
Beautiful, dense hair is a dream for many people.
Hair growth is a sophisticated biological process, which has not yet been understood.
A multitude of therapeutic measures, including drugs, surgery, and suppelements have been developed.
However, due to the diversity of the problems underlying hair loss, there is no single solution that
can address all hair loss cases. Another problem is that most of chemical drugs and hair transplantation
surgeries are not free from varying degrees of undesirable side effects on health.
Hair Million is an alternative solution to cope with hair loss problems.
Anecdotally, it shows prositive results and improvement especially for age-related hair thinning and hair loss
for a large group of people who take it as suggested. Although personal experiences and anecdotal evidences
indicate that it works, we still do not understand the mechanisms of action as to how Hair Million works to
help stop hair loss, and promote hair growth. There has been no clinical trials nor placebo controlled statistical
analysis on the efficacy of Hair Million on hair loss and hair growth. R & D costs dearly, and no one would
afford to research complex herbal ingredients, which are often not patentable at all because they are
made by mother nature.
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